methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

Base Information

Chemical Name:methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate
CAS No.:1362050-56-3
Molecular Formula:C₂₇H₂₆N₄O₃
Molecular Weight:454.528
Hs Code.:

Synonyms:methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

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Chemical Property of methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

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Technology Process of methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

There total 6 articles about methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 780764-64-9
methyl [2-(4-aminobenzyl)-4-(dimethylamino)-5-pyrimidinyl]acetate

: 1362050-56-3
methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; naphthalene-2-carboxylate; In anhydrous DMF; for 3h;

Reference yield:

: 780763-92-0
[4,6-dichloro-2-(4-nitrobenzyl)pyrimidin-5-yl]acetic acid methyl ester

: 1362050-56-3
methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethylammonium chloride; N-ethyl-N,N-diisopropylamine / anhydrous DMF / 16 h / 85 °C

2: potassium acetate / palladium 10% on activated carbon / methanol / 15 h

3: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; naphthalene-2-carboxylate / anhydrous DMF / 3 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N,N-dimethylammonium chloride; potassium acetate; N-ethyl-N,N-diisopropylamine; naphthalene-2-carboxylate; palladium 10% on activated carbon; In methanol; anhydrous DMF;

Reference yield:

: 780763-93-1
methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

: 1362050-56-3
methyl {4-(dimethylamino)-2-[4-(2-naphthoylamino)benzyl]-5-pyrimidinyl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / palladium 10% on activated carbon / methanol / 15 h

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; naphthalene-2-carboxylate / anhydrous DMF / 3 h

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; potassium acetate; naphthalene-2-carboxylate; palladium 10% on activated carbon; In methanol; anhydrous DMF;