methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

Base Information

Chemical Name:methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate
CAS No.:780763-93-1
Molecular Formula:C₁₆H₁₇ClN₄O₄
Molecular Weight:364.788
Hs Code.:

Synonyms:methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

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Chemical Property of methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

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Technology Process of methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

There total 4 articles about methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 780763-92-0
[4,6-dichloro-2-(4-nitrobenzyl)pyrimidin-5-yl]acetic acid methyl ester

: 780763-93-1
methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

Guidance literature:: With N,N-dimethylammonium chloride; N-ethyl-N,N-diisopropylamine; In anhydrous DMF; at 85 ℃; for 16h;

Reference yield:

: 39695-96-0
2-(4-nitrophenyl)ethanimidamide hydrochloride

: 780763-93-1
methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium methylate / methanol / 16 h / Heating / reflux

2: N,N-dimethyl-aniline; trichlorophosphate / 16 h / Heating / reflux

3: N,N-dimethylammonium chloride; N-ethyl-N,N-diisopropylamine / anhydrous DMF / 16 h / 85 °C

With N,N-dimethylammonium chloride; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In methanol; anhydrous DMF;

Reference yield:

: 555-21-5,34512-13-5,174848-08-9
4-Nitrophenylacetonitrile

: 780763-93-1
methyl [4-chloro-6-(dimethylamino)-2-(4-nitrobenzyl)-5-pyrimidinyl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / 1,4-dioxane; ethanol / 16 h

2: sodium methylate / methanol / 16 h / Heating / reflux

3: N,N-dimethyl-aniline; trichlorophosphate / 16 h / Heating / reflux

4: N,N-dimethylammonium chloride; N-ethyl-N,N-diisopropylamine / anhydrous DMF / 16 h / 85 °C

With hydrogenchloride; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N,N-dimethylammonium chloride; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1,4-dioxane; methanol; anhydrous DMF; ethanol;