2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

Base Information

Chemical Name:2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide
CAS No.:1355022-29-5
Molecular Formula:C₃₀H₂₃NO₃
Molecular Weight:445.518
Hs Code.:

Synonyms:2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

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Chemical Property of 2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

Chemical Property:

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Technology Process of 2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

There total 3 articles about 2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1355022-84-2
2-iodo-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

: 4187-87-5
1-Phenyl-2-propyn-1-ol

: 1355022-29-5
2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 80 ℃; Inert atmosphere;
DOI:10.1021/jo2022907

Reference yield:

: 609-67-6
2-Iodobenzoyl chloride

: 1355022-29-5
2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethyl acetate / 0 - 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In ethyl acetate; acetonitrile; 2: Sonogashira coupling;
DOI:10.1021/jo2022907

Reference yield:

: 5883-81-8
2-anilinoacetophenone

: 1355022-29-5
2-(3-hydroxy-3-phenyl-1-propynyl)-N-(2-oxo-2-phenylethyl)-N-phenylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethyl acetate / 0 - 20 °C

2: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / acetonitrile / 80 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In ethyl acetate; acetonitrile; 2: Sonogashira coupling;
DOI:10.1021/jo2022907