(3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

Base Information

Chemical Name:(3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester
CAS No.:1174504-22-3
Molecular Formula:C₂₅H₃₆O₄Si
Molecular Weight:428.644
Hs Code.:

Synonyms:(3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

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Chemical Property of (3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

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Technology Process of (3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

There total 2 articles about (3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 31469-16-6
1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: (3S)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

: 1174504-22-3
(3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

Guidance literature:: 1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene; 3-(tert-butyldiphenylsilyloxy)-1-propanal; With (S)-4-Isopropyl-3-tosyl-[1,3,2]oxazaborolidin-5-one; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;

With ammonium chloride; In dichloromethane; water; at -78 - 20 ℃;

With citric acid; In methanol; for 0.25h; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1021/jo9009003

Reference yield:

: 31469-16-6
1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: (3S)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

: 1174504-22-3
(3R)-5-(tert-butyldiphenylsilanyloxy)-3-hydroxy-2,2-dimethylpentanoic acid ethyl ester

: 1174504-20-1
C₂₈H₄₄O₄Si₂

Guidance literature:: 1-ethoxy-1-((trimethylsilyl)oxy)-2-methylpropene; 3-(tert-butyldiphenylsilyloxy)-1-propanal; With (S)-4-Isopropyl-3-tosyl-[1,3,2]oxazaborolidin-5-one; In dichloromethane; at -78 ℃; for 3h; Inert atmosphere;

With ammonium chloride; In dichloromethane; water; at -78 - 20 ℃; optical yield given as %ee; enantioselective reaction;
DOI:10.1021/jo9009003