3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Base Information

Chemical Name:3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid
CAS No.:1445879-70-8
Molecular Formula:C₂₉H₃₁N₅O₇S
Molecular Weight:593.66
Hs Code.:

Synonyms:3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Chemical Property of 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

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Technology Process of 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

There total 11 articles about 3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1445880-75-0
methyl 3-(3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-ylamino)-5-isopropoxybenzoate

: 1445879-70-8
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: With water; lithium hydroxide; In methanol; at 20 ℃; for 16h;

Reference yield:

: 591-19-5
m-Bromoaniline

: 1445879-70-8
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 10 steps

1: 18 h / 105 °C

2: diphenylether / 0.5 h / Reflux

3: water; sodium hydroxide / ethanol / 18 h / Reflux

4: diphenylether / 1.5 h / Reflux

5: chlorosulfonic acid / 3 h / 100 °C

6: N,N-dimethyl-aniline; trichlorophosphate / 1 h / 96 °C

7: dichloromethane / 0.03 h

8: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.83 h / 68 °C / Inert atmosphere

9: ethanol / 16 h / 85 °C

10: lithium hydroxide; water / methanol / 16 h / 20 °C

With chlorosulfonic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; N,N-dimethyl-aniline; sodium hydroxide; lithium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; diphenylether; ethanol; dichloromethane;

Reference yield:

: 1374869-13-2
7-bromo-4-hydroxy-2-methylquinoline-3-carboxylic acid

: 1445879-70-8
3-((3-(N-cyclopropylsulfamoyl)-7-(2,4-dimethoxypyrimidin-5-yl)-2-methylquinolin-4-yl)amino)-5-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: diphenylether / 1.5 h / Reflux

2: chlorosulfonic acid / 3 h / 100 °C

3: N,N-dimethyl-aniline; trichlorophosphate / 1 h / 96 °C

4: dichloromethane / 0.03 h

5: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 1.83 h / 68 °C / Inert atmosphere

6: ethanol / 16 h / 85 °C

7: lithium hydroxide; water / methanol / 16 h / 20 °C

With chlorosulfonic acid; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; potassium carbonate; N,N-dimethyl-aniline; lithium hydroxide; trichlorophosphate; In 1,4-dioxane; methanol; diphenylether; ethanol; dichloromethane;