3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 348640-11-9
• Molecular Formula: C14H16BrNO3
• Molecular Weight: 326.19
• Hs Code.: 2933990090
• Mol file: 348640-11-9.mol

Synonyms:3-Bromo-5-methoxyindole-1-carboxylicacid tert-butyl ester;

Chemical Property of 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.564
• Boiling Point: 403.846 °C at 760 mmHg
• Flash Point: 198.039 °C
• PSA: 40.46000
• Density: 1.379 g/cm³
• LogP: 4.19560
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

3-Bromo-5-methoxyindole-1-carboxylicacidtert-butylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 1 articles about 3-BROMO-5-METHOXYINDOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5-methoxylindole (1006-94-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate (348640-11-9)

Guidance literature:

With bromine; triethylamine; dmap; In DMF (N,N-dimethyl-formamide); at 20 - 30 ℃; for 4h;

Reference yield:

tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate (348640-11-9) + 4-methoxy-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (348640-52-8) → 2-(1-tert-Butyloxycarbonyl-5-methoxy-1H-indol-3-yl)-4-methoxy-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine (348640-51-7)

Guidance literature:

4-methoxy-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -70 - -15 ℃; for 2.08333h;

With zinc(II) chloride; In tetrahydrofuran; hexane; at -10 ℃; for 0.5h;

tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; at 60 ℃; for 16h;

Reference yield:

tert-butyl 3-bromo-5-methoxy-1H-indole-1-carboxylate (348640-11-9) + m-nitrobenzene boronic acid (13331-27-6) → tert-butyl 5-methoxy-3-(3-nitrophenyl)-1H-indole-1-carboxylate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 80 ℃; Inert atmosphere;

upstream raw materials:

5-methoxylindole

di-tert-butyl dicarbonate

Downstream raw materials:

C₁₄H₁₈BNO₅

2-(1-tert-Butyloxycarbonyl-5-methoxy-1H-indol-3-yl)-4-methoxy-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine

tert-butyl 5-methoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-indole-1-carboxylate

tert-butyl 3-(5-fluoro-4-(2-(1-hydroxycyclobutyl)thiazol-5-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridin-2-yl)-5-methoxy-1H-indole-1-carboxylate