((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

Base Information

Chemical Name:((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol
CAS No.:220047-66-5
Molecular Formula:C₂₆H₂₉NO₄S
Molecular Weight:451.587
Hs Code.:

Synonyms:((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

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Chemical Property of ((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

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Technology Process of ((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

There total 8 articles about ((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: ((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-benzyl-oxiranylmethyl-amine

: 220047-66-5
((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

Guidance literature:: With titanium(IV) isopropylate; potassium hexamethylsilazane; In tetrahydrofuran; toluene; at -70 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00989-2

Reference yield:

: 175229-12-6
(R)-3-benzyloxy-2-(tert-butoxycarbonylamino)propyl phenyl sulfone

: 220047-66-5
((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / aq. HCl / ethyl acetate / 2 h / Ambient temperature

2: 1.) titanium(IV) isopropoxide, 2.) NaBH₃CN / 1.) EtOH, room temp., 1 h, 2.) EtOH, overnight

3: 63 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

4: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature

5: 85 percent / pyridine / 24 h / 0 °C

6: 99 percent / K₂CO₃ / dimethylformamide; H₂O / 24 h / Ambient temperature

7: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C

With titanium(IV) isopropylate; hydrogenchloride; potassium hexamethylsilazane; sodium cyanoborohydride; potassium carbonate; In tetrahydrofuran; pyridine; water; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(98)00989-2

Reference yield:

: 220047-57-4
((R)-2-Benzenesulfonyl-1-benzyloxymethyl-ethyl)-((S)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl)-amine

: 220047-66-5
((3R,4S,5R)-4-Benzenesulfonyl-1-benzyl-5-benzyloxymethyl-pyrrolidin-3-yl)-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: 63 percent / K₂CO₃ / dimethylformamide / 48 h / 80 °C

2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature

3: 85 percent / pyridine / 24 h / 0 °C

4: 99 percent / K₂CO₃ / dimethylformamide; H₂O / 24 h / Ambient temperature

5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C

With titanium(IV) isopropylate; hydrogenchloride; potassium hexamethylsilazane; potassium carbonate; In tetrahydrofuran; pyridine; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4020(98)00989-2