(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Base Information

Chemical Name:(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine
CAS No.:212266-65-4
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Suppliers and Price of (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

There total 14 articles about (2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 220047-69-8
(2R,3S,4R)-3-Benzenesulfonyl-2-benzyloxymethyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 212266-65-4
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 2h;
DOI:10.1016/S0040-4020(98)00989-2

Reference yield: 96.0%

: 212266-73-4
(2R,4R)-3-Benzenesulfonyl-2-benzyloxymethyl-4-hydroxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester

: 212266-65-4
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Guidance literature:: With disodium hydrogenphosphate; sodium amalgam; In methanol; at 0 ℃; for 2h;
DOI:10.1016/S0040-4039(98)01171-X

Reference yield:

: 100-39-0
benzyl bromide

: 212266-65-4
(2S,4R)-1-tert-butoxycarbonyl-2-benzyloxymethyl-4-hydroxymethylpyrrolidine

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / 1.) NaH, 2.) n-Bu₄NI / tetrahydrofuran / 24 h / 0 °C

2: 95 percent / 3M HCl / ethyl acetate / 1 h / Ambient temperature

3: 97 percent / NaBH(OAc)3 / 1,2-dichloro-ethane / Ambient temperature

4: 94 percent / 4M HCl / tetrahydrofuran / 3 h / Ambient temperature

5: 85 percent / pyridine / 24 h / 0 °C

6: 99 percent / K₂CO₃ / H₂O; dimethylformamide / 24 h / Ambient temperature

7: 1.) Ti(Oi-Pr)4, 2.) KHMDS / 1.) THF, -78 deg C, 10 min, 2.) -70 deg C, 2 h

8: 95 percent / H₂ / Pd/C / methanol / Ambient temperature

9: 96 percent / 6percent Na-Hg, Na₂HPO₄ / methanol / 2 h / 0 °C

With pyridine; titanium(IV) isopropylate; hydrogenchloride; disodium hydrogenphosphate; sodium amalgam; hydrogen; tetra-(n-butyl)ammonium iodide; potassium hexamethylsilazane; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(98)01171-X