3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

Base Information

Chemical Name:3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde
CAS No.:959996-43-1
Molecular Formula:C₁₆H₁₉BrF₂N₂O₂Si
Molecular Weight:417.325
Hs Code.:

Synonyms:3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

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Chemical Property of 3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

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Technology Process of 3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

There total 4 articles about 3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 849062-34-6
2-bromo-4,5-difluoro phenylboronic acid

: 959996-42-0
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

: 959996-43-1
3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 80 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm301741t

Reference yield:

: 827316-45-0
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-4-carboxylic acid ethyl ester

: 959996-43-1
3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 96 h

2.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 - 50 °C

2.2: 0.5 h

3.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 24 h

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 4.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301741t

Reference yield:

: 959996-40-8
3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1Η-pyrazol-4-carboxylic acid

: 959996-43-1
3-(2-bromo-4,5-difluorophenyl)-1-((2-(trimethylsilyl)-ethoxy)methyl)-1H-pyrazole-4-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 19 h / 0 - 50 °C

1.2: 0.5 h

2.1: sodium hydrogencarbonate; Dess-Martin periodane / dichloromethane / 24 h

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / water; 1,2-dimethoxyethane / 18 h / 80 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; dimethylsulfide borane complex; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 3.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/jm301741t