Technology Process of (4R,5S)-ethyl 5-(2-(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate
There total 3 articles about (4R,5S)-ethyl 5-(2-(benzyloxy)phenyl)-2,2-dimethyl-1,3-dioxolane-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid;
In
dichloromethane;
at 20 ℃;
for 12h;
Inert atmosphere;
DOI:10.1021/ol3032126
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere
1.2: 2 h / 0 °C / Inert atmosphere
2.1: potassium hexacyanoferrate(III); hydroquinidein 1,4-phthalazinediyl diether; potassium osmate(VI) dihydrate; potassium carbonate; methanesulfonamide / tert-butyl alcohol; water / 12 h / 0 - 20 °C
3.1: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere
With
potassium osmate(VI) dihydrate; methanesulfonamide; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III);
In
tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
1.1: |Horner-Wadsworth-Emmons Olefination / 1.2: |Horner-Wadsworth-Emmons Olefination / 2.1: |Sharpless Dihydroxylation;
DOI:10.1021/ol3032126
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium hexacyanoferrate(III); hydroquinidein 1,4-phthalazinediyl diether; potassium osmate(VI) dihydrate; potassium carbonate; methanesulfonamide / tert-butyl alcohol; water / 12 h / 0 - 20 °C
2: toluene-4-sulfonic acid / dichloromethane / 12 h / 20 °C / Inert atmosphere
With
potassium osmate(VI) dihydrate; methanesulfonamide; potassium carbonate; toluene-4-sulfonic acid; hydroquinidein 1,4-phthalazinediyl diether; potassium hexacyanoferrate(III);
In
dichloromethane; water; tert-butyl alcohol;
1: |Sharpless Dihydroxylation;
DOI:10.1021/ol3032126
