trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

Base Information

Chemical Name:trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide
CAS No.:1319743-42-4
Molecular Formula:C₂₅H₂₆F₄N₂O₂
Molecular Weight:462.487
Hs Code.:

Synonyms:trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

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Chemical Property of trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

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Technology Process of trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

There total 6 articles about trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67515-56-4
4-fluoro-3-trifluoromethylbenzoyl chloride

: 1319743-51-5
trans-1-(4-amino-cyclohexylmethyl)-3,3-dimethyl-1,3-dihydro-indol-2-one

: 1319743-42-4
trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

Guidance literature:: With pyridine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 62456-15-9
methyl trans-4-amino-cyclohexanecarboxylate

: 1319743-42-4
trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / methanol / 10 - 20 °C

2.1: sodium tetrahydroborate; ethanol; calcium chloride / tetrahydrofuran / 5 - 20 °C

2.2: 10 °C / pH 11

3.1: pyridine / dichloromethane / 1 h / 0 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

4.2: 4 h / 80 °C

5.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

6.1: pyridine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; ethanol; sodium hydride; triethylamine; calcium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 239074-29-4
trans (4-hydroxymethyl-cyclohexyl)-carbamic acid tert-butyl ester

: 1319743-42-4
trans-N-[4-(3,3-dimethyl-2-oxo-2,3-dihydro-indol-1-ylmethyl)-cyclohexyl]-4-fluoro-3-trifluoromethyl-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 1 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C

2.2: 4 h / 80 °C

3.1: hydrogenchloride / 1,4-dioxane; methanol / 2 h / 20 °C

4.1: pyridine / dichloromethane; N,N-dimethyl-formamide / 20 °C

With pyridine; hydrogenchloride; sodium hydride; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;