N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

Base Information

• Chemical Name: N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide
• CAS No.: 292824-85-2
• Molecular Formula: C₁₅H₂₂ClNO₄S
• Molecular Weight: 347.863

Synonyms:N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

Chemical Property of N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

Chemical Property:

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Technology Process of N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

There total 2 articles about N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

1,4-dichloro-2-butene (764-41-0) + N-tosyldiethanolamine (7146-67-0) → N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide (292824-85-2)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 2h; pH=0;

DOI:10.1039/b002117m

Reference yield:

N,N-Bis[2-(tetrahydropyran-2-yloxy)ethyl]toluene-p-sulfonamide (292824-79-4) → N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide (292824-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / Amberlist-15 / methanol / 12 h / 20 °C

2: 32 percent / NaH / dimethylformamide / 2 h / 20 °C / pH 0

With Amberlist-15; sodium hydride; In methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Etherification;

DOI:10.1039/b002117m

Reference yield: 31.0%

N-[2-(4-chloro-but-2-enyloxy)-ethyl]-N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide (292824-85-2) → (Z)-4-(Toluene-4-sulfonyl)-1,7-dioxa-4-aza-cycloundec-9-ene

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 5.5h;

DOI:10.1039/b002117m

upstream raw materials:

1,4-dichloro-2-butene

N-tosyldiethanolamine

N,N-Bis[2-(tetrahydropyran-2-yloxy)ethyl]toluene-p-sulfonamide

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