764-41-0 Usage
Uses
1,?4-?Dichloro-?2-?butene is an organic reagent used in the preparation of heterocyclic compounds. Used in the synthesis of γ-turn peptidomimetic scaffold neuroprotectives as a JNK3 allosteric ligand.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.
General Description
A clear colorless liquid. Burns, though may be difficult to ignite. Corrosive to tissue. Denser than water and insoluble in water. Vapors heavier than air. Used to make other chemicals.
Air & Water Reactions
Highly flammable. Reacts slowly with water to form hydrochloric acid. Insoluble in water.
Reactivity Profile
Halogenated unsaturated aliphatic compounds, such as TRANS-1,4-DICHLORO-2-BUTENE, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Health Hazard
Inhalation of vapor irritates nose and throat. Contact with eyes causes intense irritation and tears. Contact of liquid with skin causes severe blistering and dermatitis. Ingestion causes severe irritation of mouth and stomach.
Fire Hazard
Special Hazards of Combustion Products: Decomposition vapors contain phosgene and hydrogen chloride gases; both are toxic and irritating.
Chemical Reactivity
Reactivity with Water Reacts slowly to form hydrochloric acid; Reactivity with Common Materials: Corrodes metal when wet; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic and
neoplastigenic data. Poison by ingestion,
inhalation, and intravenous routes.
Moderately toxic by skin contact. An experimental teratogen. Other experimental
reproductive effects. Mutation data
reported. A severe skin and eye irritant.
When heated to decomposition it emits
toxic fumes of Cl-. See also
CHLORINATED HYDROCARBONS,
ALIPHATIC .
Check Digit Verification of cas no
The CAS Registry Mumber 764-41-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 4 respectively; the second part has 2 digits, 4 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 764-41:
(5*7)+(4*6)+(3*4)+(2*4)+(1*1)=80
80 % 10 = 0
So 764-41-0 is a valid CAS Registry Number.
InChI:InChI=1/2C4H6Cl2/c2*5-3-1-2-4-6/h2*1-2H,3-4H2/b2-1+;2-1-
764-41-0Relevant articles and documents
Copperphenylsiloxane as a new structurally organized catalyst for isomerization of chloroolefins
Smirnov,Levitsky,Nevskaya,Buchachenko
, p. 204 - 204 (1997)
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Highly selective ruthenium metathesis catalysts for ethenolysis
Thomas, Renee M.,Keitz, Benjamin K.,Champagne, Timothy M.,Grubbs, Robert H.
experimental part, p. 7490 - 7496 (2011/06/27)
N-Aryl,N-alkyl N-heterocyclic carbene (NHC) ruthenium metathesis catalysts are highly selective toward the ethenolysis of methyl oleate, giving selectivity as high as 95% for the kinetic ethenolysis products over the thermodynamic self-metathesis products. The examples described herein represent some of the most selective NHC-based ruthenium catalysts for ethenolysis reactions to date. Furthermore, many of these catalysts show unusual preference and stability toward propagation as a methylidene species and provide good yields and turnover numbers at relatively low catalyst loading (500 ppm). A catalyst comparison showed that ruthenium complexes bearing sterically hindered NHC substituents afforded greater selectivity and stability and exhibited longer catalyst lifetime during reactions. Comparative analysis of the catalyst preference for kinetic versus thermodynamic product formation was achieved via evaluation of their steady-state conversion in the cross-metathesis reaction of terminal olefins. These results coincided with the observed ethenolysis selectivities, in which the more selective catalysts reach a steady state characterized by lower conversion to cross-metathesis products compared to less selective catalysts, which show higher conversion to cross-metathesis products.
PRODUCTION PROCESS FOR 1,2,3,4-TETRACHLOROHEXAFLUOROBUTANE AND REFINING PROCESS
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Page/Page column 4-5, (2010/06/14)
The production process for 1,2,3,4-tetrachlorohexafluorobutane of the present invention is characterized in that 1,2,3,4-tetrachlorobutane is reacted with fluorine in the presence of a solvent containing hydrogen fluoride. The 1,2,3,4-tetrachlorobutane may be obtained by chlorination of 3,4-dichlorobutene-1. Further, the present invention provides as well a process of refining 1,2,3,4-tetrachlorohexafluorobutane obtained in the manner described above. According to the present invention, 1,2,3,4-tetrachlorohexafluorobutane which is useful, for example, as a synthetic raw material for hexafluoro-1,3-butadiene used as an etching gas for semiconductors can industrially efficiently be produced by using 1,2,3,4-tetrachlorobutane which is a by-product of chloroprene and which has so far been disposed.
