(S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare

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Chemical Name:(S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare
CAS No.:1361249-52-6
Molecular Formula:C₂₄H₂₇N₃O₂
Molecular Weight:389.497
Hs Code.:

Synonyms:(S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare

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Chemical Property of (S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare

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Technology Process of (S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare

There total 2 articles about (S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1004904-88-4
(S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

: 1361249-52-6
(S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare

Guidance literature:: With ammonium acetate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃;
DOI:10.1039/c9cc06356k

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1361249-52-6
(S)-tert-butyl 2-(5-([1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylare

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 20 °C / Inert atmosphere

2: ammonium acetate / toluene / 16 h / 95 °C / Inert atmosphere

With ammonium acetate; N-ethyl-N,N-diisopropylamine; In toluene; acetonitrile;