(S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

Base Information

Chemical Name:(S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate
CAS No.:1004904-88-4
Molecular Formula:C₂₄H₂₇NO₅
Molecular Weight:409.482
Hs Code.:

Synonyms:(S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

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Chemical Property of (S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

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Technology Process of (S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

There total 2 articles about (S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 135-73-9
2-Bromo-4'-phenylacetophenone

: 1004904-88-4
(S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

Guidance literature:: With triethylamine; In acetonitrile;
DOI:10.1039/c9cc06356k

Reference yield:

: 92-91-1
biphenyl-4-acetaldehyde

: 1004904-88-4
(S)-2-(2-([1,1'-biphenyl]-4-yl)-2-oxoethyl)1-tert-butyl pyrrolidine-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / dichloromethane / 20 °C

2: N-ethyl-N,N-diisopropylamine / acetonitrile / 5 h / 20 °C

With bromine; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2013.02.023