N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

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Chemical Name:N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
CAS No.:1313036-54-2
Molecular Formula:C₃₁H₃₆N₈O₄
Molecular Weight:584.678
Hs Code.:

Synonyms:N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

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Chemical Property of N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

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Technology Process of N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

There total 10 articles about N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1313036-53-1
4-(3-aminophenoxy)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1313036-54-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Guidance literature:: 4-(3-aminophenoxy)-N-(2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.166667h;

acryloyl chloride; In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1313036-54-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: caesium carbonate; XPhos / palladium diacetate / tetrahydrofuran / 0.75 h / 85 °C / Microwave

4.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5.2: 0.5 h / 0 °C

With hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; platinum(IV) oxide; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Buckwald's amination;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1313036-54-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: caesium carbonate; XPhos / palladium diacetate / tetrahydrofuran / 0.75 h / 85 °C / Microwave

4.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5.2: 0.5 h / 0 °C

With hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; platinum(IV) oxide; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Buckwald's amination;