N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Base Information

Chemical Name:N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide
CAS No.:1254783-78-2
Molecular Formula:C₂₆H₂₈N₈O₃
Molecular Weight:500.56
Hs Code.:

Synonyms:N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Suppliers and Price of N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

There total 11 articles about N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1313036-54-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

: 1254783-78-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Guidance literature:: N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide; With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 4h;

With ammonia; In water;

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1254783-78-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: caesium carbonate; XPhos / palladium diacetate / tetrahydrofuran / 0.75 h / 85 °C / Microwave

4.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5.2: 0.5 h / 0 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; platinum(IV) oxide; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Buckwald's amination;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1254783-78-2
N-(3-((6-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)oxy)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethanol / 2 h

3.1: caesium carbonate; XPhos / palladium diacetate / tetrahydrofuran / 0.75 h / 85 °C / Microwave

4.1: hydrogen / platinum(IV) oxide / ethyl acetate; methanol / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.17 h / 20 °C

5.2: 0.5 h / 0 °C

6.1: hydrogenchloride / 1,4-dioxane; methanol / 4 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; platinum(IV) oxide; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; 3.1: Buckwald's amination;