1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

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Chemical Name:1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole
CAS No.:1338251-27-6
Molecular Formula:C₂₂H₂₄F₃N₅O₂
Molecular Weight:447.46
Hs Code.:

Synonyms:1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

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Chemical Property of 1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

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Technology Process of 1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

There total 4 articles about 1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.6%

: 5586-13-0
1-azido-4-(trifluoromethyl)benzene

: 4-(2-morpholinoethoxy)-N-(prop-2-ynyl)aniline

: 1338251-27-6
1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; tert-butyl alcohol; at 20 ℃; for 6h;
DOI:10.1111/j.1747-0285.2011.01172.x

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1338251-27-6
1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 6 h / Reflux

2: palladium on activated charcoal; hydrogen / ethanol

3: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran; toluene / 1 h / 45 °C / Microwave irradiation

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; palladium on activated charcoal; tetrabutylammomium bromide; hydrogen; potassium carbonate; potassium hydroxide; In tetrahydrofuran; ethanol; water; acetone; toluene; tert-butyl alcohol; 4: Huisgen cycloaddition reaction;
DOI:10.1111/j.1747-0285.2011.01172.x

Reference yield:

: 52481-41-1
4-(2-morpholinoethoxy)aniline

: 1338251-27-6
1-[4'-(trifluoromethyl)phenyl]-4-[N-[4-(2'-morpholinoethoxy)phenyl]aminomethyl]-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutylammomium bromide; potassium hydroxide / tetrahydrofuran; toluene / 1 h / 45 °C / Microwave irradiation

2: copper(ll) sulfate pentahydrate; sodium L-ascorbate / water; tert-butyl alcohol / 6 h / 20 °C

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; tetrabutylammomium bromide; potassium hydroxide; In tetrahydrofuran; water; toluene; tert-butyl alcohol; 2: Huisgen cycloaddition reaction;
DOI:10.1111/j.1747-0285.2011.01172.x