8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester

Base Information

• Chemical Name: 8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester
• CAS No.: 218899-41-3
• Molecular Formula: C₂₅H₃₀O₈
• Molecular Weight: 458.508
• Mol file: 218899-41-3.mol

Synonyms:8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester

Chemical Property of 8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester

There total 1 articles about 8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester (218899-18-4) → 8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester (218899-41-3)

Guidance literature:

With trimethylsilanyl-acetic acid ethyl ester; tetrabutyl ammonium fluoride; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1055/s-1998-2221

Reference yield: 72.0%

8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester (218899-41-3) → 5-[5,7-Dimethoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid ethyl ester (218899-32-2)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; for 3h;

DOI:10.1055/s-1998-2221

Reference yield:

8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester (218899-41-3) → 5-[5-Hydroxy-7-methoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / p-TsOH / CH₂Cl₂ / 3 h

2: 87 percent / BBr₃ / CH₂Cl₂ / 3 h / -78 - 25 °C

3: 55 percent / H₂O, Na₂CO₃ / ethanol / Heating

With water; boron tribromide; sodium carbonate; toluene-4-sulfonic acid; In ethanol; dichloromethane;

DOI:10.1055/s-1998-2221

upstream raw materials:

Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester

Downstream raw materials:

5-[5,7-Dimethoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid ethyl ester

5-[5-Hydroxy-7-methoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid ethyl ester