Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester

Base Information

• Chemical Name: Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester
• CAS No.: 218899-18-4
• Molecular Formula: C₂₅H₃₀O₈
• Molecular Weight: 458.508

Synonyms:Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester

Chemical Property of Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester

Chemical Property:

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Technology Process of Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester

There total 2 articles about Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

ethyl 6-chloro-6-oxohexanoate (1071-71-2) + 2'-hydroxy-4',6-dimethoxy-2-(p-methoxyphenyl)acetophenone (39604-68-7) → Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester (218899-18-4)

Guidance literature:

With pyridine; for 48h; Ambient temperature;

DOI:10.1055/s-1998-2221

Reference yield:

adipinic acid monoethyl ester (626-86-8) → Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester (218899-18-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 73 percent / oxalyl chloride / 2 h / Heating

2: 72 percent / pyridine / 48 h / Ambient temperature

With pyridine; oxalyl dichloride;

DOI:10.1055/s-1998-2221

Reference yield: 72.0%

Hexanedioic acid 3,5-dimethoxy-2-[2-(4-methoxy-phenyl)-acetyl]-phenyl ester ethyl ester (218899-18-4) → 5-[5,7-Dimethoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid ethyl ester (218899-32-2)

Guidance literature:

With chloro-trimethyl-silane; triethylamine; In N,N-dimethyl-formamide; for 48h; Heating;

DOI:10.1055/s-1998-2221

upstream raw materials:

ethyl 6-chloro-6-oxohexanoate

2'-hydroxy-4',6-dimethoxy-2-(p-methoxyphenyl)acetophenone

adipinic acid monoethyl ester

Downstream raw materials:

5-[5,7-Dimethoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid ethyl ester

8-(2-Hydroxy-4,6-dimethoxy-phenyl)-7-(4-methoxy-phenyl)-6,8-dioxo-octanoic acid ethyl ester

5-[5-Hydroxy-7-methoxy-3-(4-methoxy-phenyl)-4-oxo-4H-chromen-2-yl]-pentanoic acid ethyl ester

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