2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

Base Information

Chemical Name:2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone
CAS No.:1051492-96-6
Molecular Formula:C₂₀H₁₉ClO₄S
Molecular Weight:390.887
Hs Code.:

Synonyms:2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

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Chemical Property of 2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

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Technology Process of 2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

There total 6 articles about 2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.2%

: 1051493-78-7
methyl 7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-carboxylate

: 29874-00-8
(2-chlorobenzyl)magnesium chloride

: 1051492-96-6
2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

Guidance literature:: methyl 7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-carboxylate; (2-chlorobenzyl)magnesium chloride; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 20h;

With water; In tetrahydrofuran; diethyl ether;

Reference yield:

: 1072-72-6
Tetrahydrothiopyran-4-one

: 1051492-96-6
2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: toluene-4-sulfonic acid / water / 1 h / Heating / reflux

2: toluene-4-sulfonic acid / 130 - 145 °C / Neat (no solvent)

3: 1 h / 180 °C / microwave irradiation; sealed vessel; Neat (no solvent)

4: potassium carbonate / acetone / 50 °C

5: tetrahydrofuran; diethyl ether / 20 h / 0 - 20 °C

With potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; water; acetone;

Reference yield:

: 61477-16-5
4,4-dimethoxy-tetrahydro-thiopyran

: 1051492-96-6
2-(2-chlorophenyl)-1-(7-methoxy-2',3',5',6'-tetrahydrospiro[1,3-benzodioxole-2,4'-(4H)-thiopyran]-4-yl)ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / 130 - 145 °C / Neat (no solvent)

2: 1 h / 180 °C / microwave irradiation; sealed vessel; Neat (no solvent)

3: potassium carbonate / acetone / 50 °C

4: tetrahydrofuran; diethyl ether / 20 h / 0 - 20 °C

With potassium carbonate; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; acetone;