1-TRITYLIMIDAZOLE-2-CARBOXALDEHYDE

Base Information

• Chemical Name: 1-TRITYLIMIDAZOLE-2-CARBOXALDEHYDE
• CAS No.: 67478-50-6
• Molecular Formula: C23H18N2O
• Molecular Weight: 338.409
• Hs Code.: 2933290090
• Mol file: 67478-50-6.mol

Synonyms:1-Triphenylmethyl-2-imidazolecarboxaldehyde;1-Trityl-1H-imidazole-2-carboxaldehyde;2-Formyl-1-tritylimidazole;1H-Imidazole-2-carboxaldehyde,1-(triphenylmethyl)-;2-Imidazolic aldehyde, 1-triphenylmethyl-;

Chemical Property of 1-TRITYLIMIDAZOLE-2-CARBOXALDEHYDE

Chemical Property:

• Vapor Pressure: 5.09E-12mmHg at 25°C
• Melting Point: 190-193 ºC
• Refractive Index: 1.612
• Boiling Point: 547 °C at 760 mmHg
• PKA: 3.31±0.31(Predicted)
• Flash Point: 284.6 °C
• PSA: 34.89000
• Density: 1.1 g/cm³
• LogP: 4.53580
• Storage Temp.: 2-8°C

Purity/Quality:

90.0%Min ^*data from raw suppliers

1-Tritylimidazole-2-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-TRITYLIMIDAZOLE-2-CARBOXALDEHYDE

There total 11 articles about 1-TRITYLIMIDAZOLE-2-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

trityl chloride (76-83-5) + 2-imidazolecarbaldehyde (10111-08-7) → 1-(triphenylmethyl)-1H-imidazole-2-carboxaldehyde (67478-50-6)

Guidance literature:

2-imidazolecarbaldehyde; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

trityl chloride; In N,N-dimethyl-formamide; for 48h;

DOI:10.1016/j.ejmech.2011.01.042

Reference yield: 76.0%

N-tritylimidazole (15469-97-3) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 1-(triphenylmethyl)-1H-imidazole-2-carboxaldehyde (67478-50-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/j.bmcl.2013.01.088

Reference yield: 75.0%

N-tritylimidazole (15469-97-3) → 1-(triphenylmethyl)-1H-imidazole-2-carboxaldehyde (67478-50-6)

Guidance literature:

N-tritylimidazole; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h;

With N,N-dimethyl-formamide; In tetrahydrofuran; hexanes; at -78 ℃; for 1.66667h;

With ammonium chloride; In tetrahydrofuran; hexanes; water;

upstream raw materials:

N-trityl-4⁽⁵⁾-iodoimidazole

N,N-dimethyl-formamide

Methyl formate

N-tritylimidazole

Downstream raw materials:

benzyl((1-(triphenylmethyl)imidazol-2-yl)methyl)amine

ethyl (2E)-3-(1-triphenylmethyl-1H-imidazol-2-yl)acrylate

3-hydroxy-1-(5-phenethylthiophen-2-yl)-3-(1-trityl-1H-imidazol-2-yl)propan-1-one

Refernces

• 1、 Patanapongpibul, Manee,Zhang, Changde,Chen, Guanglin,Guo, Shanchun,Zhang, Qiang,Zheng, Shilong,Wang, Guangdi,Chen, Qiao-Hong. "Optimization of diarylpentadienones as chemotherapeutics for prostate cancer". . p. 4751 - 4760. Retrieved 2018/08/21.
• 2、 Omar,Mahran,Ghatge,Chowdhury,Bamane,El-Araby,Abdulmalik,Safo. "Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents". . p. 6353 - 6370. Retrieved 2015/06/08.