1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Base Information

Chemical Name:1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]
CAS No.:1093379-08-8
Molecular Formula:C₁₈H₂₇NOS
Molecular Weight:305.484
Hs Code.:

Synonyms:1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Suppliers and Price of 1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

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Technology Process of 1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

There total 15 articles about 1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1093379-00-0
1-(cyclohexylmethyl)spiro[piperidine-4,4'-thieno[3,2-c]pyran]

: 1093379-08-8
1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 6h; under 3375.34 Torr;

Reference yield:

: 1070709-21-5
1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

: 1093379-08-8
1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Guidance literature:: Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -20 °C

2: palladium on activated charcoal; hydrogen / methanol / 6 h / 20 °C / 3375.34 Torr

With palladium on activated charcoal; boron trifluoride diethyl etherate; hydrogen; In methanol; dichloromethane;
DOI:10.1021/jm300302p

Reference yield:

: (E/Z)-3-bromo-2-(2-methoxyvinyl)thiophene

: 1093379-08-8
1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene-4-sulfonic acid / methanol / 24 h / Heating / reflux

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.28 - 0.3 h / -78 °C

2.2: 3.5 h / -78 - 20 °C

3.1: toluene-4-sulfonic acid; trimethyl orthoformate / methanol / 3 h / 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -20 - 0 °C

5.1: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 3375.34 Torr

With n-butyllithium; boron trifluoride diethyl etherate; hydrogen; toluene-4-sulfonic acid; trimethyl orthoformate; palladium 10% on activated carbon; toluene-4-sulfonic acid; In tetrahydrofuran; methanol; hexane; dichloromethane;