1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Base Information

• Chemical Name: 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]
• CAS No.: 1070709-21-5
• Molecular Formula: C₁₉H₂₉NO₂S
• Molecular Weight: 335.511

Synonyms:1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Chemical Property of 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Chemical Property:

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Technology Process of 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

There total 12 articles about 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] (1070709-27-1) + benzyl bromide (100-39-0) → 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] (1070709-21-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Reflux;

DOI:10.1021/jm8007739

Reference yield: 95.0%

6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] (1070709-27-1) + Cyclohexylmethyl bromide (2550-36-9) → 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] (1070709-21-5)

Guidance literature:

With potassium carbonate; In acetonitrile; for 24h; Product distribution / selectivity; Heating / reflux;

Reference yield: 68.0%

2-{3-[1-(cyclohexylmethyl)-4-hydroxypiperidin-4-yl]-2-thienyl}acetaldehyde dimethyl acetal (1070709-06-6) → 1-(cyclohexylmethyl)-6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran] (1070709-21-5)

Guidance literature:

With toluene-4-sulfonic acid; trimethyl orthoformate; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm8007739

upstream raw materials:

6'-methoxy-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

Cyclohexylmethyl bromide

2-{3-[1-(cyclohexylmethyl)-4-hydroxypiperidin-4-yl]-2-thienyl}acetaldehyde dimethyl acetal

benzyl bromide

Downstream raw materials:

1-(cyclohexylmethyl)spiro[piperidine-4,4'-thieno[3,2-c]pyran]

1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]-6'-carbonitrile

1-(cyclohexylmethyl)-6',7'-dihydrospiro[piperidine-4,4'-thieno[3,2-c]pyran]

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