{1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

Base Information

Chemical Name:{1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine
CAS No.:73735-38-3
Molecular Formula:C₂₉H₃₃FN₄O₂
Molecular Weight:488.605
Hs Code.:

Synonyms:{1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

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Chemical Property of {1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

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Technology Process of {1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

There total 4 articles about {1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75970-64-8
1-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-1H-benzimidazol-2-amine dihydrobromide

: 73735-38-3
{1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

Guidance literature:: With sodium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 90 ℃;
DOI:10.1021/jm00150a029

Reference yield:

: 73734-07-3
(1H-benzimidazol-2-yl)-(1-ethoxycarbonyl-piperidin-4-yl)amine

: 73735-38-3
{1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 40 percent / sodium carbonate, potassium iodide / dimethylformamide / 70 °C

2: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

3: Na₂CO₃, KI / dimethylformamide / 90 °C

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029

Reference yield:

: 84501-68-8
ethyl 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]amino]-1-piperidinecarboxylate

: 73735-38-3
{1-[2-(2,5-Dimethoxy-phenyl)-ethyl]-piperidin-4-yl}-[1-(4-fluoro-benzyl)-1H-benzoimidazol-2-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / 48 percent hydrobromic acid / 1 h / Heating

2: Na₂CO₃, KI / dimethylformamide / 90 °C

With hydrogen bromide; sodium carbonate; potassium iodide; In N,N-dimethyl-formamide;
DOI:10.1021/jm00150a029