4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine

Base Information

• Chemical Name: 4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine
• CAS No.: 894788-52-4
• Molecular Formula: C₁₂H₁₁BrN₄O₃S
• Molecular Weight: 371.214
• Mol file: 894788-52-4.mol

Synonyms:4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine

Chemical Property of 4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine

Chemical Property:

Purity/Quality:

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Technology Process of 4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine

There total 1 articles about 4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo[4,5-e][1,2,4]thiadiazine (894788-60-4) + 1-Bromo-2-bromomethyl-benzene (3433-80-5) → 4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine (894788-52-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 30 ℃; for 10h;

DOI:10.3987/COM-06-10707

Reference yield:

4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine (894788-52-4) + benzyl bromide (100-39-0) → 2-benzyl-4-(o-bromobenzyl)-7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo[4,5-e][1,2,4]thiadiazine

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 40 - 50 ℃; for 12h;

DOI:10.3390/11110827

Reference yield:

4-(2-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine (894788-52-4) + 1-Chloro-4-(chloromethyl)benzene (104-83-6) → 2-(p-chlorobenzyl)-4-(o-bromobenzyl)-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 12h;

DOI:10.3390/11110827

upstream raw materials:

7-methyl-1,1,3-trioxo-2,4-dihydro-pyrazolo[4,5-e][1,2,4]thiadiazine

1-Bromo-2-bromomethyl-benzene