(2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine

Base Information

• Chemical Name: (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine
• CAS No.: 220956-08-1
• Molecular Formula: C₃₄H₃₃F₃N₂O₂
• Molecular Weight: 558.643

Synonyms:(2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine

Chemical Property of (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine

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Technology Process of (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine

There total 4 articles about (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

benzyl bromide (100-39-0) + (S)-1,1,1-Trifluoro-3-[(E)-(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-ylimino]-2-phenyl-propan-2-ol (220956-00-3) → (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine (220956-08-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1002/(SICI)1521-3773(19981231)37:24<3428::AID-ANIE3428>3.0.CO;2-P

Reference yield:

2,2,2-Trifluoroacetophenone (434-45-7) → (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine (220956-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent

2: 82 percent / NaH / dimethylformamide / 1.5 h / 20 °C

With sodium hydride; In N,N-dimethyl-formamide; 1: Addition / 2: benzylation;

DOI:10.1021/jo991049u

Reference yield:

(S)-1-methylenamino-2-(1,1-diphenyl-1-methoxymethyl)pyrrolidine (220955-83-9) → (2S,2'S)-1-[2'-benzyloxy-2'-phenyl-3',3',3'-(trifluoro)propyleneamino]-2-(1''-methoxy-1'',1''-diphenyl)pyrrolidine (220956-08-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 52 percent

2: 82 percent / NaH / dimethylformamide / 1.5 h / 20 °C

With sodium hydride; In N,N-dimethyl-formamide; 1: Addition / 2: benzylation;

DOI:10.1021/jo991049u

upstream raw materials:

benzyl bromide

(S)-1,1,1-Trifluoro-3-[(E)-(S)-2-(methoxy-diphenyl-methyl)-pyrrolidin-1-ylimino]-2-phenyl-propan-2-ol

2,2,2-Trifluoroacetophenone

(S)-(-)-1-amino-2-(1'-methoxy-1',1'-diphenylmethyl)pyrrolidine

Downstream raw materials:

1-nitroso-2-(1'-methoxy-1',1'-diphenyl)pyrrolidine

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