1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline

Base Information

• Chemical Name: 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline
• CAS No.: 919082-26-1
• Molecular Formula: C₂₇H₂₉NO₅
• Molecular Weight: 447.531
• Mol file: 919082-26-1.mol

Synonyms:1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline

Chemical Property of 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline

There total 10 articles about 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-(3-Benzyloxy-4-methoxy-phenyl)-N-[2-(2,3,4-trimethoxy-phenyl)-ethyl]-acetamide (24214-36-6) → 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline (919082-26-1)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jo061810h

Reference yield:

2-(2,3,4-trimethoxyphenyl)ethylamine (3937-16-4) → 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline (919082-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane; water / 2 h / 20 °C

2: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium carbonate; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; 2: Bischler-Napieralski reaction;

DOI:10.1021/jo061810h

Reference yield:

O-benzylhomoisovanillic acid (5487-33-2) → 1-(3-benzyloxy-4-methoxy-benzyl)-5,6,7-trimethoxy-3,4-dihydro-isoquinoline (919082-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2: sodium carbonate / dichloromethane; water / 2 h / 20 °C

3: trichlorophosphate / N,N-dimethyl-formamide / 3 h / 20 °C

With oxalyl dichloride; sodium carbonate; N,N-dimethyl-formamide; trichlorophosphate; In dichloromethane; water; N,N-dimethyl-formamide; 3: Bischler-Napieralski reaction;

DOI:10.1021/jo061810h

upstream raw materials:

2-(3-Benzyloxy-4-methoxy-phenyl)-N-[2-(2,3,4-trimethoxy-phenyl)-ethyl]-acetamide

2-(2,3,4-trimethoxyphenyl)ethylamine

O-benzylhomoisovanillic acid

2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride

Downstream raw materials:

ethyl 1-(3-benzyloxy-4-methoxyphenyl)-2-(2,4-dibenzyloxy-5-methoxyphenyl)-7,8,9-trimethoxy-5,6-dihydropyrrolo[2,1-a]isoquinoline-3-carboxylate

14-(3-acetoxy-4-methoxyphenyl)-3-acetoxy-2,10,11,12-tetramethoxy-8,9-dihydro-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

14-(3-acetoxy-4-methoxyphenyl)-3-acetoxy-2,10,11,12-tetramethoxy-6H-chromeno[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one

Lamellarin T