[3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride

Base Information

Chemical Name:[3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride
CAS No.:54313-33-6
Molecular Formula:C16H15ClO3
Molecular Weight:290.746
Hs Code.:
DSSTox Substance ID:DTXSID10560887
Wikidata:Q82444515

Synonyms:54313-33-6;[3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride;SCHEMBL2394315;DTXSID10560887;WXNFTMQQDNUEKB-UHFFFAOYSA-N;3-benzyloxy-4-methoxy-phenylacetyl chloride;(3-benzyloxy-4-methoxyphenyl)acetyl chloride

Suppliers and Price of [3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of [3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:290.0709720
Heavy Atom Count:20
Complexity:302

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC(=O)Cl)OCC2=CC=CC=C2

Technology Process of [3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride

There total 11 articles about [3-(Benzyloxy)-4-methoxyphenyl]acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 54313-33-6
2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride

Guidance literature:

Reference yield: 94.0%

: 5487-33-2
O-benzylhomoisovanillic acid

: 54313-33-6
2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride

Guidance literature:: With oxalyl dichloride; In benzene;
DOI:10.1016/j.tetlet.2009.10.114

Reference yield:

: 621-59-0
isovanillin

: 54313-33-6
2-(3-(benzyloxy)-4-methoxyphenyl)acetyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: K₂CO₃ / dimethylformamide / 5 h / 40 - 50 °C

2: NaBH₄, 0.5N aq. NaOH / tetrahydrofuran / 2.5 h / Ambient temperature

3: SOCl₂ / tetrahydrofuran; dimethylformamide / 1 h / Ambient temperature

4: 18-crown-6 / acetonitrile / 7 h / Heating

5: aq. KOH / ethanol / 4 h / Heating

6: thionyl chloride / toluene / 2 h / 80 °C

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; 18-crown-6 ether; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/jm980212v