(E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

Base Information

Chemical Name:(E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol
CAS No.:625450-81-9
Molecular Formula:C₂₅H₄₃NO₈Si
Molecular Weight:513.704
Hs Code.:

Synonyms:(E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

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Chemical Property of (E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

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Technology Process of (E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

There total 6 articles about (E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 326606-09-1
(4R,5S,7R)-4-(tert-butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(5-nitro-2,3,6-trimethoxy-phenyl)-oct-2-enoic acid methyl ester

: 625450-81-9
(E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

Guidance literature:: With diisobutylaluminium hydride;
DOI:10.1021/jo034870l

Reference yield:

: 326606-17-1
(3S,5S,6S)-3-[(1S,3R)-1-methoxy-3-methyl-4-(5-nitro-2,3,6-trimethoxy-phenyl)-butyl]-5,6-bis-(4-methoxy-phenyl)-[1,4]dioxan-2-ol

: 625450-81-9
(E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / LiCl / acetonitrile

2: 93 percent / CAN

3: 91 percent / imidazole

4: 94 percent / DIBAL-H

With 1H-imidazole; ammonium cerium(IV) nitrate; diisobutylaluminium hydride; lithium chloride; In acetonitrile;
DOI:10.1021/jo034870l

Reference yield:

: 326606-16-0
(3S,5S,6S)-3-[(1S,3R)-1-hydroxy-3-methyl-4-(5-nitro-2,3,6-trimethoxy-phenyl)-butyl]-5,6-bis-(4-methoxy-phenyl)-[1,4]dioxan-2-one

: 625450-81-9
(E)-(4R,5S,7R)-4-(tert-Butyl-dimethyl-silanyloxy)-5-methoxy-7-methyl-8-(2,3,6-trimethoxy-5-nitro-phenyl)-oct-2-en-1-ol

Guidance literature:: Multi-step reaction with 6 steps

1: 91 percent / proton sponge / CH₂Cl₂ / 8 h / 20 °C

2: 91 percent / DIBAL-H

3: 93 percent / LiCl / acetonitrile

4: 93 percent / CAN

5: 91 percent / imidazole

6: 94 percent / DIBAL-H

With 1H-imidazole; Proton Sponge; ammonium cerium(IV) nitrate; diisobutylaluminium hydride; lithium chloride; In dichloromethane; acetonitrile;
DOI:10.1021/jo034870l