N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

Base Information

Chemical Name:N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide
CAS No.:1312563-38-4
Molecular Formula:C₁₉H₂₁ClN₂O₃
Molecular Weight:360.84
Hs Code.:

Synonyms:N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

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Chemical Property of N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

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Technology Process of N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

There total 5 articles about N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1312563-49-7
C₃₅H₃₉ClN₂O₃Si

: 1312563-38-4
N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

Guidance literature:: C₃₅H₃₉ClN₂O₃Si; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 12h;

With water; ammonium chloride; In tetrahydrofuran;

Reference yield:

: 123855-51-6
tert-butyl 4-(hydroxymethyl)piperidin-1-carboxylate

: 1312563-38-4
N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 18 h / 0 - 50 °C

2: 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate / dichloromethane / 1 h / 20 °C

3: triethylamine / dmap / tetrahydrofuran / 12 h / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

With 2,6-dimethylpyridine; trimethylsilyl trifluoromethanesulfonate; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1312563-46-4
C₂₈H₃₅NO₂Si

: 1312563-38-4
N-(4-chlorophenyl)-4-((4-hydroxyphenoxy)methyl)-piperidine-1-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dmap / tetrahydrofuran / 12 h / 20 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 12 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; dmap; In tetrahydrofuran;