2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl

Base Information

• Chemical Name: 2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl
• CAS No.: 1194840-70-4
• Molecular Formula: C₂₅H₂₇NO₄S
• Molecular Weight: 437.56
• Mol file: 1194840-70-4.mol

Synonyms:2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl

Chemical Property of 2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl

Chemical Property:

Purity/Quality:

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Technology Process of 2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl

There total 1 articles about 2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S(S))-(-)-2-iodo-1-methoxy-3-(p-tolylsulfinyl)benzene (1194840-60-2) + tert-butyl N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate (159624-15-4) → 2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl (1194840-70-4)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; caesium carbonate; In 1,4-dioxane; water; at 70 ℃; for 1h; diastereoselective reaction; Inert atmosphere;

DOI:10.1021/ol9020755

Reference yield: 74.0%

2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl (1194840-70-4) → 2-methoxy-2'-amino-6-(p-tolylsulfinyl)biphenyl

Guidance literature:

2-methoxy-2'-N-tert-butoxycarbonylamino-6-p-tolylsulfinyl biphenyl; With trifluoroacetic acid; In dichloromethane; for 2h; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; Inert atmosphere;

DOI:10.1021/ol9020755

upstream raw materials:

(S(S))-(-)-2-iodo-1-methoxy-3-(p-tolylsulfinyl)benzene

tert-butyl N-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbamate