Technology Process of (S(S))-(-)-2-iodo-1-methoxy-3-(p-tolylsulfinyl)benzene
There total 5 articles about (S(S))-(-)-2-iodo-1-methoxy-3-(p-tolylsulfinyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S(S))-(+)-1-methoxy-3-(p-tolylsulfinyl)benzene;
With
lithium diisopropyl amide;
In
tetrahydrofuran;
at -78 ℃;
for 2h;
With
iodine;
In
tetrahydrofuran;
at -78 - 25 ℃;
DOI:10.1016/j.tet.2016.01.047
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: thionyl chloride / toluene / 1 h / 20 °C / Cooling with ice
2.1: pyridine / toluene / 6 h / 20 °C / Cooling with ice
3.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / Inert atmosphere; Cooling with acetone-dry ice
3.2: 1 h / -78 °C / Inert atmosphere
4.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
4.2: 0.17 h / -78 °C / Inert atmosphere
With
pyridine; n-butyllithium; thionyl chloride; lithium diisopropyl amide;
In
tetrahydrofuran; hexane; toluene;
DOI:10.1002/adsc.201300446
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / tetrahydrofuran; hexane / 1.5 h / Inert atmosphere; Cooling with acetone-dry ice
1.2: 1 h / -78 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C / Inert atmosphere
2.2: 0.17 h / -78 °C / Inert atmosphere
With
n-butyllithium; lithium diisopropyl amide;
In
tetrahydrofuran; hexane;
DOI:10.1002/adsc.201300446
