(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide

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Chemical Name:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide
CAS No.:405262-85-3
Molecular Formula:C₂₆H₂₄ClN₅O₄S
Molecular Weight:538.027
Hs Code.:

Synonyms:(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide

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Chemical Property of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide

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Technology Process of (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide

There total 2 articles about (E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 150728-13-5
4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine

: 405262-63-7
(E)-2-(2,4,6-Trimethyl-phenyl)-ethenesulfonic acid amide

: 405262-85-3
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide

Guidance literature:: (E)-2-(2,4,6-Trimethyl-phenyl)-ethenesulfonic acid amide; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

4,6-dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1248/cpb.49.1593

Reference yield:

: 576-83-0
2,4,6-trimethylphenyl bromide

: 405262-85-3
(E)-N-[6-chloro-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]-2-(2,4,6-trimethylphenyl)ethenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 45 percent / PPh₃; Pd(OAc)2; Et₃N / dimethylformamide / 12 h / 130 °C

2.1: NaH / dimethylformamide / 0.17 h / 20 °C

2.2: 80 percent / dimethylformamide / 2 h / 20 °C

With palladium diacetate; sodium hydride; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; 1.1: Heck reaction;
DOI:10.1248/cpb.49.1593