S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

Base Information

Chemical Name:S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate
CAS No.:1082053-90-4
Molecular Formula:C₁₅H₂₆O₃S₂Si
Molecular Weight:346.587
Hs Code.:

Synonyms:S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

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Technology Process of S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

There total 2 articles about S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 125597-86-6
S-(2-hydroxyethyl) 4-toluenethiosulfonate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1082053-90-4
S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 55h;
DOI:10.1021/acs.jmedchem.1c00799

Reference yield:

: 28519-50-8
potassium thiotosylate

: 1082053-90-4
S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere; Darkness

2: 1H-imidazole / N,N-dimethyl-formamide / 55 h / 20 °C

With 1H-imidazole; In N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.1c00799

Reference yield: 28.0%

: 1174020-25-7,2064219-13-0
(2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid

: 1082053-90-4
S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate

: C₂₁H₃₄N₂O₃SSi

Guidance literature:: (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxylic acid; With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2-mercaptopyridine N-oxide; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere; Darkness;

S-(2-((tert-butyldimethylsilyl)oxy)ethyl) 4-methylbenzenesulfonothioate; In dichloromethane; at 0 ℃; for 0.5h; Inert atmosphere; Irradiation;
DOI:10.1021/acs.jmedchem.1c00799