tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate
• CAS No.: 1586042-47-8
• Molecular Formula: C₁₉H₁₈ClF₂N₅O₃S
• Molecular Weight: 469.899

Synonyms:tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

Chemical Property of tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

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Technology Process of tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate

There total 1 articles about tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-chloro-1-methyl-1H-pyrazol-4-amine + 5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid (1270034-25-7) → tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate (1586042-47-8)

Guidance literature:

Reference yield: 17.0%

potassium fluoride dihydrate + 3,6-dihydro-2H-pyran-4-boronic acid pinacol ester + tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate (1586042-47-8) → 5-amino-2-(2,6-difluorophenyl)-N-[5-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-pyrazol-4-yl]thiazole-4-carboxamide (1586039-47-5)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; methanol; water;

Reference yield:

potassium fluoride dihydrate + tert-butyl 4-(5-chloro-1-methyl-1H-pyrazol-4-ylcarbamoyl)-2-(2,6-difluorophenyl)thiazol-5-ylcarbamate (1586042-47-8) + 3,4-dihydro-2H-pyran-6-boronic acid pinacol ester → tert-butyl 2-(2,6-difluorophenyl)-4-(5-(2-ethoxytetrahydro-2H-pyran-2-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)thiazol-5-ylcarbamate (1586046-34-5)

Guidance literature:

In tetrahydrofuran; ethanol; water;

upstream raw materials:

5-[(tert-butoxycarbonyl)amino]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxylic acid

Downstream raw materials:

5-amino-2-(2,6-difluorophenyl)-N-[5-(2-methoxytetrahydropyran-2-yl)-1-methyl-pyrazol-4-yl]thiazole-4-carboxamide

tert-butyl 2-(2,6-difluorophenyl)-4-(5-(2-ethoxytetrahydro-2H-pyran-2-yl)-1-methyl-1H-pyrazol-4-ylcarbamoyl)thiazol-5-ylcarbamate

5-amino-2-(2,6-difluorophenyl)-N-[5-(3,6-dihydro-2H-pyran-4-yl)-1-methyl-pyrazol-4-yl]thiazole-4-carboxamide

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