2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

Base Information

Chemical Name:2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile
CAS No.:518342-97-7
Molecular Formula:C₃₀H₂₅NSi
Molecular Weight:427.621
Hs Code.:

Synonyms:2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

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Chemical Property of 2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

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Technology Process of 2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

There total 11 articles about 2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 518342-65-9
2-iodo-5-(trimethylsilanylethynyl)benzonitrile

: 518342-74-0
2-ethyl-4-ethynyl-1-(phenylethynyl)benzene

: 518342-97-7
2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(02)01409-6

Reference yield:

: 536-74-3
phenylacetylene

: 518342-97-7
2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / PdCl₂(PPh₃)2; CuI; PPh₃ / i-Pr₂NEt / tetrahydrofuran / 72 h / 20 °C

2: 94 percent / K₂CO₃ / methanol

3: 69 percent / PdCl₂(PPh₃)2; CuI; i-Pr₂NEt / tetrahydrofuran / 24 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling / 3: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)01409-6

Reference yield:

: 132131-24-9
5-iodoanthranilonitrile

: 518342-97-7
2-(3-ethyl-4-phenylethynylphenylethynyl)-5-trimethylsilanylethynylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: Pd(PPh₃)2Cl₂; CuI; triethylamine / 20 °C

2.1: BF₃*Et₂O; t-BuONO / diethyl ether / -20 - 5 °C

2.2: 70 percent / NaI; I₂ / acetonitrile / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tert.-butylnitrite; boron trifluoride diethyl etherate; triethylamine; In diethyl ether; 1.1: Sonogashira coupling;
DOI:10.1016/S0040-4020(02)01409-6