4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol

Base Information

• Chemical Name: 4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol
• CAS No.: 1029359-48-5
• Molecular Formula: C₂₃H₂₀FN₃O₂
• Molecular Weight: 389.429

Synonyms:4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol

Chemical Property of 4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol

Chemical Property:

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Technology Process of 4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol

There total 1 articles about 4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[{6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}ethynyl]phenyl acetate (1029359-46-3) → 4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol (1029359-48-5)

Guidance literature:

Reference yield:

4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol (1029359-48-5) + N-chloroethylpiperidine hydrochloride (2008-75-5) → 3-[4-(2-fluorophenoxy)piperidin-1-yl]-6-{[4-piperidin-1-ylethoxy]phenylethynyl}-pyridazine (1029359-52-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

potassium hydroxide (1310-58-3) + 4-(2-{6-[4-(2-fluorophenoxy)piperidino]-3-pyridazinyl}-1-ethynyl)phenol (1029359-48-5) → 4-(2-{6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}ethynyl)phenol potassium salt (1029359-50-9)

Guidance literature:

With methanol; In tetrahydrofuran; at 20 ℃; for 1h;

upstream raw materials:

4-[{6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}ethynyl]phenyl acetate

Downstream raw materials:

3-[4-(2-fluorophenoxy)piperidin-1-yl]-6-{[4-piperidin-1-ylethoxy]phenylethynyl}-pyridazine

4-(2-{6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}ethynyl)phenol potassium salt

4-({6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl}ethynyl)phenyl 2-furoate

4-({[6-[4-(2-fluorophenoxy)piperidin-1-yl]pyridazin-3-yl]ethynyl}phenoxy)morpholine

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