1310-58-3

Basic information

• Product Name: Potassium hydroxide
• Synonyms: POTASH;POTASH CAUSTIC;POTASH LYE;POTASSIUM HYDRATE;POTASSIUM HYDROXIDE STANDARD;POTASSIUM HYDROXIDE;POTASSIUM HYDROXIDE ETHANOLIC;POTASSIUM OXIDE HYDRATE
• CAS NO: 1310-58-3
• Molecular Formula: HO*K
• Molecular Weight: 56.11
• EINECS: 215-181-3
• Product Categories: INORGANIC & ORGANIC CHEMICALS;Inorganics;Acids&Bases;Essential Chemicals;Reagent Grade;Analytical Reagents;Drying Agents;Special Applications;Base Solutions;Base SolutionsVolumetric Solutions;By Reference Material;Reference Material Hydrochloric acid;Titration;Volumetric Solutions;HPLC Buffers - SolutionChromatography/CE Reagents;HPLC;HPLC Buffer;HPLC Buffers;Solution;Chromatography/CE Reagents;Eluent concentrates for ICAlphabetic;Ion Chromatography;P;PON - PT;Base SolutionsTitration;Solution containers (VOLPAC);Chemical Synthesis;Inorganic Bases;Synthetic Reagents;Decomposition Reagents;Atomic Absorption Spectroscopy (AAS);Digestion Reagents;Pure Salts for Melting Digestions (Trace SELECT)Analytical/Chromatography;Trace Analysis Reagents;Base ConcentratesConcentrates (e.g. FIXANAL);Concentrates (e.g. FIXANAL);metal hydroxide;KOH
• Mol File: 1310-58-3.mol
• Article Data: 1

Chemical Properties

• Melting Point: 361 °C(lit.)
• Boiling Point: 1320°C
• Flash Point: 52 °F
• Appearance: white/powder
• Density: 1.450 g/mL at 20 °C
• Vapor Pressure: 1 mm Hg ( 719 °C)
• Refractive Index: n20/D 1.421
• Storage Temp.: 0-6°C
• Solubility: H2O: 1 M at 20 °C, clear, colorless
• Water Solubility: soluble
• Sensitive: Air Sensitive & Hygroscopic
• Stability: Stable, but very hygroscopic. Dissolves exothermically in water. Incompatible with most metals, strong acids, acid chlorides, or
• Merck: 14,7640
• CAS DataBase Reference: Potassium hydroxide(CAS DataBase Reference)
• NIST Chemistry Reference: Potassium hydroxide(1310-58-3)
• EPA Substance Registry System: Potassium hydroxide(1310-58-3)

Safety Data

• Hazard Codes: C,F,T,Xi
• Statements: 34-35-22-11-39/23/24/25-23/24/25-36/38-36/37-67-52/53
• Safety Statements: 7-16-36/37-45-36/37/39-26-61
• RIDADR: UN 2924 3/PG 2
• WGK Germany: 1
• RTECS: TT2100000
• F: 3
• TSCA: Yes
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 1310-58-3(Hazardous Substances Data)

Usage

Uses

Potassium hydroxide is used in making liquidsoap and potassium salts, in electroplatingand lithography, in printing inks, as a mordantfor wood, and finds wide applicationsin organic syntheses and chemical analyses.

Hazard

Toxic by ingestion and inhalation, strong caustic, handle with gloves or tongs, corrosive to tissue. Eye, skin and upper respiratory tract irritant.

Description

Potassium hydroxide(KOH) is highly basic, forming strongly alkaline solutions in water and other polar solvents. These solutions are capable of deprotonating many acids, even weak ones. Potassium hydroxide is used to make soft soap, in scrubbing and cleaning operations, as a mordant for woods, in dyes and colorants, and for absorbing carbon dioxide. Other principle uses of caustic potash are in the preparation of several potassium salts, acid-base titrations, and in orgainic sytheses. Also, KOH is an electrolyte in certain alkaline storage batteries and fuel cells. Potassium hydroxide is used in neutralization reactions to yield potassium salts. Aqueous potassium hydroxide is employed as the electrolyte in alkaline batteries based on nickel-cadmium and manganese dioxide-zinc. Alcoholic KOH solutions are also used as an effective method for cleaning glassware. KOH works well in the manufacture of biodiesel by catalyzing transesterification of the triglycerides in vegetable oil.

Reactions

Potassium hydroxide is a very strong base, more basic than caustic soda. It is neutralized by acids. The solution on evaporation yields the corresponding potassium salt: KOH + HCl → K+ + Clˉ+ H2O Action of bromine or iodine on a warm concentrated solution of KOH forms bromate and bromide or iodate and iodide, respectively: 3Br2 + 6OHˉ→ BrO3ˉ + 5Brˉ + 3H2O 3I2 + 6OHˉ → IO3ˉ + 5Iˉ + 3H2O When carbon dioxide is passed through its aqueous solution and the solution evaporated, potassium bicarbonate is formed: KOH + CO2 → KHCO3 Reaction with carbon monoxide at 100 to 200°C at a CO pressure above 7 atm yields potassium formate: KOH + CO → HCOOK Reaction with phenol in dilute methanol solution forms potassium phenoxide: KOH + C6H5OH → C6H5OK + H2O Reaction with boric acid and hydrofluoric acid forms potassium tetrafluoroborate, KBF4: KOH + H3BO3 + 4HF → KBF4 + 4H2O An alcoholic solution of potassium hydroxide reacts with an alcoholic solution of carbon disulfide to form potassium ethylxanthogenate, C2H5OCS2K KOH + C2H5OH + CS2 → C2H5OCS2K + H2O Reaction with sodium borohydride forms potassium borohydride: POTASSIUM HYDROXIDE 759KOH + NaBH4 → KBH4 + NaOH Reaction with hydrofluoric acid forms potassium bifluoride: KOH + 2HF → KHF2 + H2O Half neutralization of a phthalic anhydride solution forms potassium hydrogen phthalate.

Uses

potassium hydroxide is used as an emulsifier in lotions and as an alkali in liquid soaps, protective creams, and shaving preparations. Depending on the concentration used, it can be highly irritating to the skin and/or cause a burning sensation.

Waste Disposal

Dilute with large volume of water, neutralize and flush to sewer

Potential Exposure

KOH is generally used as an alkali and in the manufacture of other potassium compounds.

Chemical Properties

Potassium hydroxide occurs as a white or nearly white fused mass. It is available in small pellets, flakes, sticks and other shapes or forms. It is hard and brittle and shows a crystalline fracture. Potassium hydroxide is hygroscopic and deliquescent; on exposure to air, it rapidly absorbs carbon dioxide and water with the formation of potassium carbonate. Soluble in water, alcohol, glycerol; slightly soluble in ether.

Regulatory Status

GRAS listed. Accepted for use in Europe in certain food applications. Included in the FDA Inactive Ingredients Database (injections, infusions, and oral capsules and solutions). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Indications

Potassium hydroxide (KOH) is a strong alkali that digests proteins and epidermal debris. In one study, 10% solution was applied b.i.d. to each lesion for 30 days with excellent clearance. The side effects included stinging of the lesion and one case of secondary infection. Also reported were the occurrence of a hypertrophic scar as well as some persistent or transitory hyper- and hypopigmentation. The same authors who used the 5% KOH solution completed further studies and they found it to be as effective-yet with decreased side effects.

Uses

Potassium Hydroxide is a water-soluble food additive and bleaching agent. upon exposure to air it readily absorbs carbon dioxide and moisture and deliquesces. it is used to destroy the bitter chemical constituents in olives that will be used as black olives.

Reactivity Profile

POTASSIUM HYDROXIDE absorbs moisture readily forming caustic solution that attacks aluminum and zinc. A piece of potassium hydroxide causes liquid chlorine dioxide to explode [Mellor 2:289. 1946-47]. 1,2-dichloroethylene and potassium hydroxide forms chloroacetylene, which is explosive and spontaneously flammable in air. Potassium hydroxide is highly toxic [Rutledge 1968. p. 134]. A reaction between n-nitrosomethylurea and potassium hydroxide in n-butyl ether resulted in an explosion due to the formation of diazomethane [Schwab 1972]. Potassium persulfate and a little potassium hydroxide and water ignited a polythene (polyethylene) liner of a container by release of heat and oxygen [MCA Case History 1155. 1955]. Using potassium hydroxide to dry impure tetrahydrofuran, which contains peroxides, may be hazardous. Explosions have occurred in the past. Sodium hydroxide behaves in a similar way as potassium hydroxide [NSC Newsletter Chem. Soc. 1967]. A strong base. Forms caustic solution in water. [Merck 11th ed. 1989].

General Description

A white solid. Corrosive to metals and tissue. Used in soap manufacture, bleach, as an electrolyte in alkaline batteries, and as a food additive.

storage

splash goggles and impermeable gloves should be worn at all times when handling these substances to prevent eye and skin contact. Operations with metal hydroxide solutions that have the potential to create aerosols should be conducted in a fume hood to prevent exposure by inhalation. NaOH and KOH generate considerable heat when dissolved in water; when mixing with water, always add caustics slowly to the water and stir continuously. Never add water in limited quantities to solid hydroxides. Potassium hydroxide should be stored in an airtight, nonmetallic container in a cool, dry place, separated from acids and incompatible substances.

Shipping

UN1814 (solution) & UN1813 (solid); Potassium hydroxide, solid or solution, Hazard class: 8; Labels: 8-Corrosive material.

Air & Water Reactions

Hydrolysis generates enough heat to ignite adjacent combustible material [Haz. Chem. Data 1966]. Dissolves in water (with liberation of heat, may steam and spatter. Solution is basic (alkaline). Deliquescent

Chemical Properties

Pure potassium hydroxide is a solid at room temperature, though it is often sold as a liquid. Potassium hydroxide is a strong alkaline substance that dissociates completely in water into the potassium ion (K+) and hydroxide ion (OH-). The dissolution in water generates heat, so a vigorous reaction can occur when potassium hydroxide is added to water. The vapor pressure of the substance is very low and the melting point is high. Potassium hydroxide solutions attack aluminium and its alloys under formation of hydrogen gas. It can be neutralised with acids (e.g. hydrochloric acid) giving the corresponding potassium salts of the acids, which are usually pH neutral and non-corrosive.

Chemical Properties

Potassium hydroxide, caustic potash, potassium hydrate, KOH, white solid, formed (1) by reaction of potassium carbonate and calcium hydroxide in H2O, and then separation of the solution and evaporation, (2) by electrolysis of potassium chloride under the proper conditions, and evaporation.

Uses

Potassium hydroxide has many different functions and uses. It is primarily used as an intermediate in industrial manufacturing processes, such as the manufacture of fertilisers, potassium carbonate or other potassium salts and organic chemicals. It is also used in the manufacture of detergents and in alkaline batteries. Small-scale uses include drain cleaning products, paint removers and degreasing agents. manufacture of liquid soap; mordant for wood; absorbing CO2; mercerizing cotton; paint and varnish removers; electroplating, photoengraving and lithography; printing inks; in analytical chemistry and in organic syntheses. Pharmaceutic aid (alkalizer).

Safety

Potassium hydroxide is widely used in the pharmaceutical and food industries and is generally regarded as a nontoxic material at low concentrations. At high concentrations it is a corrosive irritant to the skin, eyes, and mucous membranes. (rat, oral): 0.273 g/kg

Pharmaceutical Applications

Potassium hydroxide is widely used in pharmaceutical formulations to adjust the pH of solutions. It can also be used to react with weak acids to form salts. Therapeutically, potassium hydroxide is used in various dermatological applications.

Health Hazard

Causes severe burns of eyes, skin, and mucous membranes. Potassium hydroxide is a strongly alkaline, hydrophilic substance and therefore solid potassium hydroxide is highly corrosive. It reacts with fat and can cause irreversible damage to any site of contact with the body (for example skin or eyes). Solutions of potassium hydroxide in water at concentrations above 0.5% (w/w) are irritating at points of contact and, at higher concentrations, the solutions can be corrosive. Potassium hydroxide does not cause skin allergies. Because of the corrosive properties of potassium hydroxide, its ingestion can be fatal. Under normal conditions of handling and use, potassium hydroxide in solution will dissociate into its constituent ions and, if ingested, will not be systemically available in the body as such.

Physical properties

White rhombohedral deliquescent crystal; density 2.044 g/cm3; melts at 360°C; vaporizes around 1,320°C; highly soluble in water, 107 g/100mL at 15°C and 178 g/100mL at 100°C; aqueous solution highly alkaline, pH of 0.1M solution is 13.5; soluble in alcohol and glycerol; insoluble in ether and liquid ammonia.

Safety Profile

Poison by ingestion. An eye irritant and severe human skin irritant. Very corrosive to the eyes, skin, and mucous membranes. Mutation data reported. Ingestion may cause violent pain in throat and epigastrium, hematemesis, collapse. Stricture of esophagus may result if substance is not immedately fatal. Above 84' it reacts with reducing sugars to form poisonous carbon monoxide gas. Violent, exothermic reaction with water. Potentially explosive reaction with bromoform + crown ethers, chlorine dioxide, nitrobenzene, nitromethane, nitrogen trichloride, peroxidized tetrahydrofuran, 2,4,6- trinitrotoluene. Reaction with ammonium hexachloroplatinate(2-) + heat forms a heat- sensitive explosive product. Violent reaction or ignition under the appropriate condtions with acids, alcohols, p-bis(l,3- dbromoethyl)benzene, cyclopentadene, germanium, hyponitrous acid, maleic anhydride, nitroalkanes, 2-nitrophenol, potassium peroxodisulfate, sugars, 2,2,3,3- tetrafluoropropanol, thorium dicarbide. When heated to decomposition it emits toxic fumes of K2O. See also SODIUM HYDROXIDE.

Production Methods

Potassium hydroxide is produced commerically by electrolysis of a saturated solution of potassium chloride in brine using mercury cells consisting of a titanium anode and mercury cathode. Potassium reacts with mercury forming the amalgam which, on treatment with water, forms potassium hydroxide and hydrogen. Other types of electrolytic cells, although not so commonly used today, are also known. In a diaphragm type cell that separates the cell into anode and cathode compartments, an aqueous solution of potassium chloride is electrolyzed. Potassium hydroxide and hydrogen are produced at the cathode and chlorine is liberated at the anode. The solution discharged from the cell is evaporated to concentrate potassium hydroxide and precipitate potassium chloride. Potassium hydroxide also may be made by reacting potassium superoxide with water: 2KO2 + 2H2O → 2KOH + H2O2 + O2

Flammability and Explosibility

Sodium hydroxide and potassium hydroxide are not flammable as solids or aqueous solutions.

Incompatibilities

Potassium hydroxide is a strong base and is incompatible with any compound that readily undergoes hydrolysis or oxidation. Violent reaction with acids, alcohols, water, metals (when wet), halogenated hydrocarbons; maleic anhydride. Heat is generated if KOH comes in contact with water and carbon dioxide from the air. It should not be stored in glass or aluminum containers, Corrosive to zinc, aluminum, tin and lead in the presence of moisture releasing combustible/explosive hydrogen gas. Can absorb water from air and give off sufficient heat to ignite surrounding combustible materials.

Applications

▼▲ Industry Application Role/benefit Chemical manufacturer Manufacturer of other potassium compounds Precursor/source of potassium Electrochemistry Manufacture of batteries and fuel cells Electrolyte/ good conductors of electricity Wet processing of semiconductors Etchant/corrosivity and alkalinity Biomass fuels Manufacturing biodiesel from oils and fats Catalyst/KOH works well in the manufacture of biodiesel by transesterification of the triglycerides in vegetable oil Food Rinse or chemical peel for fruits and vegetables Additive in rinse solution/corrosivity and alkalinity Chocolate,cocoa,soft drink,ice cream,etc. Stabilizer,thickener and pH regulator Cleaning Manufacture of "potassium soaps" Saponification agent/has better softness and greater solubility than sodium soaps Industrial cleaners for oven,drain,driveway,concrete,pipe,etc. Additive/alkalinity and good solubility for grease Liquid soaps, lotions, shampoos, hairsprays, and denture cleaners Additive/helps to increase softness and solubility Medicine Disbudding calves horns and dissolving scales and hair in veterinary medicine Dissolving solution/good solubility for keratin Dissolving warts and cuticles in humans Diagnose fungal infections Diagnose agent Production of potassium boron hydrogen, spironolactone, progesterone and testosterone propionate, etc. Raw material Agriculture Potassium fertilizers (potassium phosphate) Raw material/source of potassium Paper Separation of lignin from cellulose fibers Additive/alkalinity Dyeing Manufacture of tripolycyanamide dye Raw material Textile Dyeing, bleaching and mercerizing textiles Additive/corrosivity and alkalinity Manufacture of artificial fiber and polyester fiber Main raw material Chemical analysis Titration of acids Titration agent/alkalinity Others Bleaching textiles Bleaching agent Absorption of CO2, SO3 and NO3 in gas streams Absorption agent/alkalinity Absorption of H2O Absorption agent/ hygroscopicity of anhydrous potassium hydroxide

Production Methods

Potassium hydroxide is made by the electrolysis of potassium chloride. Commercial grades may contain chlorides as well as other impurities.

Purification Methods

Its carbonate content can be reduced by rinsing KOH sticks rapidly with water prior to dissolving them in boiled out distilled water. Alternatively, a slight excess of saturated BaCl2 or Ba(OH)2 can be added to the solution which, after shaking well, is set aside so that the BaCO3 is allowed to separate out. Davies and Nancollas [Nature 165 237 1950] rendered KOH solutions carbonate free by ion exchange using a column of Amberlite IR-100 in the OH-form.

InChI:InChI=1/K.H2O/h;1H2/q+1;

Synthetic route

potassium fluoride + calcium hydroxide → calcium fluoride + potassium hydroxide (1310-58-3)

Conditions	Yield
In water at 70℃; for 2h; Product distribution / selectivity;

potassium hydroxide (1310-58-3) + diethyl 2-(2,2-diethoxyethyl)malonate (21339-47-9) → potassium 4,4-diethoxy-2-ethoxycarbonylbutanoate (944334-17-2)

Conditions	Yield
With ethanol at 20℃; for 4h;	100%

potassium hydroxide (1310-58-3) + C13H16N4O4 (943846-31-9) → C12H13N4O4(1-)*K(1+) (943844-60-8)

Conditions	Yield
With water In tetrahydrofuran; acetonitrile at 20℃; for 1h;	100%

potassium hydroxide (1310-58-3) + 1-methyl-3-morpholin-4-ylmethyl-1H-indole-6-carboxylic acid methyl ester (1056001-95-6) → potassium 1-methyl-3-morpholin-4-ylmethyl-1H-indole-6-carboxylate (1056001-96-7)

Conditions	Yield
With water; isopropyl alcohol at 55℃; for 24h;	100%

potassium hydroxide (1310-58-3) + 3-piperidin-1-ylmethyl-1H-indole-5-carboxylic acid methyl ester (1056002-06-2) → potassium 3-piperidin-1-ylmethyl-1H-indole-5-carboxylate (1056002-07-3)

Conditions	Yield
With water; isopropyl alcohol at 55℃; for 24h;	100%

potassium hydroxide (1310-58-3) + 3,4-Dihydro-1H-isoquinoline-2.6-dicarboxylic acid 2-tert-butyl ester-6-methyl ester (170097-66-2) → potassium 2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-isoquinoline-6-carboxylate (1055948-66-7)

Conditions	Yield
With water; isopropyl alcohol at 80℃; for 24h;	100%

potassium hydroxide (1310-58-3) + 2-(4-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-6-carboxylic acid methyl ester (1055948-69-0) → potassium 2-(4-trifluoromethyl-benzyl)-1,2,3,4-tetrahydro-isoquinoline-6-carboxylate (1055948-70-3)

Conditions	Yield
With water; isopropyl alcohol at 80℃; for 16h;	100%

potassium hydroxide (1310-58-3) + 4-fluoro-N-(3-{[5-methoxy-2-(tetrahydro-2H-pyran-4-ylmethyl)phenyl]amino}quinoxalin-2-yl)benzenesulfonamide (1050514-78-7) → 4-fluoro-N-(3-{[5-methoxy-2-(tetrahydro-2H-pyran-4-ylmethyl)phenyl]amino}quinoxalin-2-yl)benzenesulfonamide potassium salt

Conditions	Yield
In water	100%

potassium hydroxide (1310-58-3) + N-[3-({2-[(1-acetylpiperidin-4-yl)methyl]-5-methoxyphenyl}amino)quinoxalin-2-yl]-1-methyl-1H-imidazole-4-sulfonamide (1050514-79-8) → N-[3-({2-[(1-acetylpiperidin-4-yl)methyl]-5-methoxyphenyl}amino)quinoxalin-2-yl]-1-methyl-1H-imidazole-4-sulfonamide potassium salt

Conditions	Yield
In water	100%

potassium hydroxide (1310-58-3) + N-(3-{[2-(cyclohexylmethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide (1050514-83-4) → N-(3-{[2-(cyclohexylmethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide potassium salt

Conditions	Yield
In water	100%

potassium hydroxide (1310-58-3) + N-(3-{[5-methoxy-2-(tetrahydro-2H-thiopyran-4-ylmethyl)phenyl]amino}quinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide (1050514-86-7) → N-(3-{[5-methoxy-2-(tetrahydro-2H-thiopyran-4-ylmethyl)phenyl]amino}quinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide potassium salt

Conditions	Yield
In water	100%

potassium hydroxide (1310-58-3) + N-(3-{[2-(2-hydroxyethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide (1050514-93-6) → N-(3-{[2-(2-hydroxyethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)-1-methyl-1H-imidazole-4-sulfonamide potassium salt

Conditions	Yield
In water	100%

potassium hydroxide (1310-58-3) + N-[3-({5-methoxy-2-[2-(methylsulfonyl)ethyl]phenyl}amino)quinoxalin-2-yl]ethanesulfonamide (1050515-04-2) → N-[3-({5-methoxy-2-[2-(methylsulfonyl)ethyl]phenyl}amino)quinoxalin-2-yl]ethanesulfonamide potassium salt

Conditions	Yield
In water	100%

potassium hydroxide (1310-58-3) + 4-(2-hydroxyethoxy)-N-(3-{[2-(2-hydroxyethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)benzenesulfonamide (1050515-18-8) → 4-(2-hydroxyethoxy)-N-(3-{[2-(2-hydroxyethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)benzenesulfonamide potassium salt

Conditions	Yield
In water	100%

carbon disulfide (75-15-0) + potassium hydroxide (1310-58-3) + quinolin-6-yl-acetic acid hydrazide (5622-41-3) → N'-(2-quinolin-6-yl-acetyl)-hydrazinecarbodithioic acid, potassium salt

Conditions	Yield
In ethanol at 0℃; for 15h;	100%

carbon disulfide (75-15-0) + potassium hydroxide (1310-58-3) + [3-(1-methyl-1H-pyrazol-4-yl)quinolin-6-yl]acetic acid hydrazide (1022092-08-5) → N'-{2-[3-(1-methyl-1H-pyrazol-4-yl)-quinolin-6-yl]-acetyl}-hydrazinecarbodithioic acid, potassium salt

Conditions	Yield
In ethanol at 0℃; for 15h; Heating / reflux;	100%

potassium hydroxide (1310-58-3) + Elinogrel → N-[(5-chlorothiophene-2-yl)sulfonyl]-N'-(4-(6-fluoro-7-(methylamino)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)urea potassium salt

Conditions	Yield
In tetrahydrofuran for 2h; Product distribution / selectivity;	100%
In tetrahydrofuran; water at 50℃; for 0.583333h; Product distribution / selectivity;	96%
In water; acetonitrile at 30 - 50℃; for 1h; Product distribution / selectivity;	60.6%

potassium hydroxide (1310-58-3) + (+/-)-ethyl (4-methyl-1-piperazinyl)(6-methyl-3-pyridinyl)acetate (1092477-83-2) → potassium (+/-)-(4-methyl-1-piperazinyl)(6-methyl-3-pyridinyl)acetate (1092477-84-3)

Conditions	Yield
With methanol; water at 20℃; for 72h;	100%

potassium hydroxide (1310-58-3) + (+/-)-2-(3-chloro-2-pyridinyl)-2-(4-methyl-1-piperazinyl)acetohydrazide (1092477-88-7) → potassium (+/-)-(3-chloro-2-pyridinyl)(4-methyl-1-piperazinyl)carboxylate

Conditions	Yield
With methanol; water at 20℃;	100%

potassium hydroxide (1310-58-3) + (+/-)-1,1-dimethylethyl 4-[2-(ethyloxy)-2-oxo-1-(2-pyridinyl)ethyl]-1-piperazinecarboxylate (444893-99-6) → (+/-)-potassium (4-{[(1,1-dimethylethyl)oxy]carbonyl}-1-piperazinyl)(2-pyridinyl)carboxylate (1092477-91-2)

Conditions	Yield
With methanol; water at 20℃;	100%

potassium hydroxide (1310-58-3) + (+/-)-ethyl (4-methyl-1-piperazinyl)(4-methyl-2-pyridinyl)acetate (1092477-95-6) → (+/-)-potassium (4-methyl-1-piperazinyl)(4-methyl-2-pyridinyl)carboxylate

Conditions	Yield
With methanol; (+/-)-methyl bromo(2-chloro-3-pyridinyl)acetate at 20℃;	100%

potassium hydroxide (1310-58-3) + (+/-)-methyl (4-methyl-1-piperazinyl)(6-methyl-2-pyridinyl)acetate (1092477-99-0) → (+/-)-potassium (4-methyl-1-piperazinyl)(6-methyl-2-pyridinyl)acetate (1092478-00-6)

Conditions	Yield
With methanol; water for 3h;	100%

potassium hydroxide (1310-58-3) + (+/-)-ethyl (4-methyl-1-piperazinyl)(2-pyridinyl)acetate (1092478-02-8) → potassium (+/-)-(4-methyl-1-piperazinyl)(2-pyridinyl)acetate (1092478-03-9)

Conditions	Yield
With methanol; water at 20℃;	100%

potassium hydroxide (1310-58-3) + ethyl (2,6-dimethyl-3-pyridinyl)[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]acetate (1092478-20-0) → potassium (2,6-dimethyl-3-pyridinyl)[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]acetate (1092478-21-1)

Conditions	Yield
With methanol; water at 20℃; for 93h;	100%

potassium hydroxide (1310-58-3) + methyl 5-amino-2-chloro-4-methoxybenzoate (104253-47-6) → potassium 5-amino-2-chloro-4-methoxybenzoate (1143025-71-1)

Conditions	Yield
In ethanol at 70℃; for 2h;	100%

potassium hydroxide (1310-58-3) + 2-amino-6-fluoro-1,3-benzothiazole (348-40-3) → 2-amino-5-fluorothiophenol potassium salt (365214-14-8)

Conditions	Yield
In water at 113 - 115℃; for 8h; Heating / reflux;	99.7%

potassium hydroxide (1310-58-3) + N-{3-[(5-methoxy-2-{[1-(methylsulfonyl)piperidin-4-yl]methyl}phenyl)amino]quinoxalin-2-yl}-1-methyl-1H-imidazole-4-sulfonamide (1050515-19-9) → N-{3-[(5-methoxy-2-{[1-(methylsulfonyl)piperidin-4-yl]methyl}phenyl)amino]quinoxalin-2-yl}-1-methyl-1H-imidazole-4-sulfonamide potassium salt

Conditions	Yield
In water	99%

potassium hydroxide (1310-58-3) + 7-(tetrazol-5-ylmethyloxy)-3',4',5-trimethoxyflavone (1092093-60-1) → 7-(tetrazol-5-ylmethyloxy)-3',4',5-trimethoxyflavone, potassium salt

Conditions	Yield
In water at 20℃; for 1h;	99%

potassium hydroxide (1310-58-3) + N-[3-({2-[(1-acetylpiperidin-4-yl)methyl]-5-methoxyphenyl}amino)quinoxalin-2-yl]pyridine-3-sulfonamide (1050514-80-1) → N-[3-({2-[(1-acetylpiperidin-4-yl)methyl]-5-methoxyphenyl}amino)quinoxalin-2-yl]pyridine-3-sulfonamide potassium salt

Conditions	Yield
In water	98%

potassium hydroxide (1310-58-3) + N-(3-{[2-(cyclohexylmethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)methanesulfonamide (1050514-84-5) → N-(3-{[2-(cyclohexylmethyl)-5-methoxyphenyl]amino}quinoxalin-2-yl)methanesulfonamide potassium salt

Conditions	Yield
In water	98%

potassium hydroxide (1310-58-3) + N-[3-({5-methoxy-2-[2-(methylsulfonyl)ethyl]phenyl}amino)quinoxalin-2-yl]-1-methyl-1H-imidazole-4-sulfonamide (1050514-98-1) → N-[3-({5-methoxy-2-[2-(methylsulfonyl)ethyl]phenyl}amino)quinoxalin-2-yl]-1-methyl-1H-imidazole-4-sulfonamide potassium salt

Conditions	Yield
In water	98%

Upstream product

• 10361-37-2 Barium chloride 
• 7789-23-3 Potassium fluoride 
• 1333-74-0 Hydrogen 
• 7439-97-6 MERCURY 

Downstream Products

• 14481-26-6 Potassium titanium oxalate 
• 13205-46-4 4-ISOPROPOXYBENZOIC ACID 
• 14484-69-6 Potassium fluoroaluminate 
• 175278-44-1 4-(BENZYLTHIO)-3-NITROBENZALDEHYDE 
• 175278-53-2 4-[(2-FURYLMETHYL)THIO]-3-NITROBENZALDEHYDE 
• 123640-41-5 2-BROMO-6-(1H-PYRAZOL-1-YL)PYRIDINE 
• 2831-60-9 2-(2,4-DINITROPHENOXY)ETHANOL 
• 632-16-6 2,3-Dimethylthiophene 
• 877-24-7 Potassium hydrogen phthalate 
• 6935-27-9 2-Benzylaminopyridine 
• 5910-89-4 2,3-Dimethylpyrazine 
• 2720-73-2 AMYLXANTHIC ACID POTASSIUM SALT 
• 593-29-3 Potassium stearate 
• 16502-01-5 1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE 
• 66-84-2 D-Glucosamine hydrochloride 
• 10043-22-8 oxalic acid, potassium salt 
• 13769-43-2 Potassium metavanadate 
• 1483-54-1 2-Amino-4-trifluoromethylbenzonitrile 
• 22580-55-8 PYRROLIDONE HYDROTRIBROMIDE 
• 270262-95-8 4-(CYCLOHEXYLTHIO)-3-NITROBENZALDEHYDE 
• 270262-96-9 4-(4-CHLOROPHENYLTHIO)-3-NITROBENZALDEHYDE 
• 4433-40-3 5-Hydroxymethyluracil 
• 4919-33-9 4-ETHOXYPHENYLACETIC ACID 
• 590-00-1 Potassium sorbate 
• 61657-67-8 3,5-DIBROMO-2-ETHOXYBENZALDEHYDE 
• 71010-52-1 GELLAN GUM 
• 7778-49-6 Tripotassium citrate 
• 866-84-2 Potassium citrate 
• 9004-98-2 POLYETHYLENE GLYCOL MONOOLEYL ETHER 
• 921-53-9 Potassium tartrate 
• 94-53-1 Piperonylic acid 
• 94-66-6 2-Allylcyclohexanone 
• 996-31-6 Potassium lactate 

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Related news

Recovery of Potassium hydroxide (cas 1310-58-3) from strong potassium aluminate solutions using solvent extraction with alkyl phenols08/17/2019

Solvent extraction of potassium hydroxide from strong potassium aluminate solutions was investigated systematically, where alkyl phenols with the stereo-hindrance of alkyl substituents to the hydroxyl functional group were used as extractants. The research focused on organic phase, phase equilib...detailed

Decomposition of monazite concentrate in Potassium hydroxide (cas 1310-58-3) solution08/16/2019

Alkali roasting of monazite concentrate using potassium hydroxide in place of sodium hydroxide could allow for the coproduction of tripotassium phosphate, which would be of greater economic value than trisodium phosphate. Therefore, this study aims to assess the ability of potassium hydroxide to...detailed

An electrodialytic Potassium hydroxide (cas 1310-58-3) eluent generator suited to small bore ion chromatography08/15/2019

An electrodialytic potassium hydroxide eluent generator (EDG) well-suited to small-bore (2 mm i.d.) ion chromatography (sIC) system is described. The basic configuration of EDG cartridge is much similar to that of conventional counterpart except lower void volume, which was measured to be ˜9 μL...detailed