(E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

Base Information

Chemical Name:(E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime
CAS No.:1375217-78-9
Molecular Formula:C₂₉H₂₆N₄O₂
Molecular Weight:462.551
Hs Code.:

Synonyms:(E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

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Chemical Property of (E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

Chemical Property:

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Technology Process of (E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

There total 6 articles about (E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369588-27-1
(E)-1-(6-methyl-pyridin-2-yl)-ethanone O-prop-2-yn-1-yl-oxime

: 1375217-79-0
4-benzyloxy-6'-bromo-6-methyl-[2,2]bipyridinyl

: 1375217-78-9
(E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

Guidance literature:: With diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 55 ℃; for 3h;

Reference yield:

: 139487-69-7
6-bromopyridine-2-carbonyl chloride

: 1375217-78-9
(E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / -20 - 20 °C

2: trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / Reflux

3: potassium carbonate / N,N-dimethyl-formamide

4: diisopropylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 3 h / 55 °C

With trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 4: Sonogashira Coupling;

Reference yield:

: 21190-87-4
6-bromo-pyridine-2-carboxylic acid

: 1375217-78-9
(E)-1-(6-methyl-pyridin-2-yl)-ethanone-O-[3-(4'-benzyloxy-6'-methyl-[2,2']bipyridinyl-6-yl)-prop-2-ynyl]-oxime

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C / Reflux

2: triethylamine / dichloromethane / -20 - 20 °C

3: trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / Reflux

4: potassium carbonate / N,N-dimethyl-formamide

5: diisopropylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 3 h / 55 °C

With oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; potassium carbonate; triethylamine; diisopropylamine; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; 5: Sonogashira Coupling;