6-bromopicolinic acid chloride

Base Information

• Chemical Name: 6-bromopicolinic acid chloride
• CAS No.: 139487-69-7
• Molecular Formula: C6H3BrClNO
• Molecular Weight: 220.453
• Hs Code.: 2933399990
• Mol file: 139487-69-7.mol

Synonyms:6-bromo-pyridine-2-carboxylic acid chloride;6-bromopicolinic acid chloride;6-bromo-pyridin-2-carboxylic acid chloride;6-bromopicolinoyl chloride;6-Bromo-pyridine-2-carbonyl chloride;2-bromopicolinic acid chloride;6-bromopyridine-2carboxylic acid chloride;

Chemical Property of 6-bromopicolinic acid chloride

Chemical Property:

• PSA: 29.96000
• LogP: 2.22310

Purity/Quality:

99% ^*data from raw suppliers

2-Bromopyridine-6-carbonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-bromopicolinic acid chloride

There total 4 articles about 6-bromopicolinic acid chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

6-bromo-pyridine-2-carboxylic acid (21190-87-4) → 6-bromopyridine-2-carbonyl chloride (139487-69-7)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

ethyl γ-aminobutyrate hydrochloride (6937-16-2) → 4-(6-bromo-2-pyridylcarbonylamino)-butyric acid ethyl ester (139487-70-0) + 6-bromopyridine-2-carbonyl chloride (139487-69-7)

Guidance literature:

With triethylamine; In 1,4-dioxane; water;

Reference yield:

2-bromo-6-methylpyridine (5315-25-3) → 6-bromopyridine-2-carbonyl chloride (139487-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: KMnO₄ / H₂O / 24 h / Heating

2: SOCl₂ / 12 h / Heating

With potassium permanganate; thionyl chloride; In water;

DOI:10.1039/p19960001927

upstream raw materials:

6-bromo-pyridine-2-carboxylic acid

2-bromo-6-methylpyridine

ethyl γ-aminobutyrate hydrochloride

Downstream raw materials:

6-bromo-pyridine-2-carboxylic acid amide

6-bromo-N-methylpicolinamide

C₁₉H₂₀BrClN₄O

2-amino-1-(6-bromopyridin-2-yl)ethanone hydrochloride