4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane

Base Information

• Chemical Name: 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane
• CAS No.: 74461-32-8
• Molecular Formula: C₃₁H₄₁N₃O₇S₃
• Molecular Weight: 663.88
• Mol file: 74461-32-8.mol

Synonyms:4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane

Chemical Property of 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane

There total 5 articles about 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

1,5,9-Tritosyl-1,5,9-triazanonane (35980-64-4) + diethylene glycol ditosylate (7460-82-4) → 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane (74461-32-8)

Guidance literature:

1,5,9-Tritosyl-1,5,9-triazanonane; With caesium carbonate; In N,N-dimethyl-formamide; for 1h; Inert atmosphere;

diethylene glycol ditosylate; In N,N-dimethyl-formamide; for 77h; Inert atmosphere;

DOI:10.1002/anie.201707872

Reference yield: 86.0%

1,1'-oxybis(2-bromo-ethane) (5414-19-7) + 1,5,9-Tritosyl-1,5,9-triazanonane (35980-64-4) → 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane (74461-32-8)

Guidance literature:

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; In toluene; for 10h; Heating;

Reference yield:

1,5,9-Tritosyl-1,5,9-triazanonane (35980-64-4) + N,N'-Bis(p-tolylsulfonyl)-1,5-diamino-3-oxapentane (59945-34-5) → 4,8,12-tris(p-tolylsulphonyl)-1-oxa-4,8,12-triazacyclotetradecane (74461-32-8)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

DOI:10.1021/acs.organomet.0c00129

upstream raw materials:

1,1'-oxybis(2-bromo-ethane)

1,5,9-Tritosyl-1,5,9-triazanonane

diethylene glycol ditosylate

bis(3-aminopropyl)amine