2-BROMO-5-CHLOROANILINE

Base Information

• Chemical Name: 2-BROMO-5-CHLOROANILINE
• CAS No.: 823-57-4
• Molecular Formula: C6H5 Br Cl N
• Molecular Weight: 206.469
• Hs Code.: 29214200
• Mol file: 823-57-4.mol

Synonyms:Aniline,2-bromo-5-chloro- (7CI,8CI); 2-Bromo-5-chloroaniline;2-Bromo-5-chlorobenzenamine

Chemical Property of 2-BROMO-5-CHLOROANILINE

Chemical Property:

• Vapor Pressure: 0.00897mmHg at 25°C
• Melting Point: 38 °C
• Boiling Point: 128 °C / 7mmHg
• PKA: 1.48±0.10(Predicted)
• Flash Point: 114.5°C
• PSA: 26.02000
• Density: 1.722g/cm³
• LogP: 3.26590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility.: soluble in Methanol

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-5-chloroaniline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-5-CHLOROANILINE

There total 8 articles about 2-BROMO-5-CHLOROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-chloro-5-bromonitrobenzene (41513-04-6) → 2-bromo-5-chloroaniline (823-57-4)

Guidance literature:

2-chloro-5-bromonitrobenzene; With tin(ll) chloride; In ethyl acetate; for 1h; Heating / reflux;

With sodium hydrogencarbonate; In water; at 0 - 20 ℃;

Reference yield: 80.0%

4-bromo-1-chloro-2-nitrobenzene (16588-24-2) → 2-bromo-5-chloroaniline (823-57-4)

Guidance literature:

With iron; acetic acid; at 80 ℃; for 1h;

Reference yield: 68.0%

3-chloro-aniline (108-42-9) → 2-bromo-5-chloroaniline (823-57-4)

Guidance literature:

With hydrogen bromide; dimethyl sulfoxide; for 15h; Ambient temperature;

DOI:10.1039/cc9960002679

upstream raw materials:

2-chloro-5-bromonitrobenzene

3-chloro-aniline

4-bromo-1-chloro-2-nitrobenzene

4-Chloro-2-nitroaniline

Downstream raw materials:

5-chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2yl)benzenamine

1-bromo-4-chloro-2-iodo-benzene

(2-bromo-5-chlorophenyl)(methyl)sulfane

5-chloro-2-(pyridin-2-yl)benzenamine

Refernces

• 1、 Sheng, Yao,Wang, Xueguang,Yue, Shengnan,Cheng, Gonglin,Zou, Xiujing,Lu, Xionggang. "In Situ Synthesized Silica-Supported Co@N-Doped Carbon as Highly Efficient and Reusable Catalysts for Selective Reduction of Halogenated Nitroaromatics". . p. 4632 - 4641. Retrieved 2020/07/30.
• 2、 -. "PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY". Paragraph 0678; 0679. . Retrieved 2017/07/05.