adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

Base Information

Chemical Name:adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate
CAS No.:438469-01-3
Molecular Formula:C₃₂H₄₆N₇O₁₃PSi₂
Molecular Weight:823.901
Hs Code.:

Synonyms:adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

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Chemical Property of adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

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Technology Process of adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

There total 4 articles about adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 438468-98-5
N-(4-(bromomethyl)-3-nitrobenzoyl)iminodiacetic acid bis[2-(trimethylsilyl)ethyl] ester

: 60-92-4
cAMP

: 438469-00-2
adenosine 3',5'-cyclic([Sp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

: 438469-01-3
adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

Guidance literature:: cAMP; In ethanol;

N-(4-(bromomethyl)-3-nitrobenzoyl)iminodiacetic acid bis[2-(trimethylsilyl)ethyl] ester; With sodium carbonate; In N,N-dimethyl acetamide; at 80 ℃; for 1h; Further stages.;
DOI:10.1021/jo020040g

Reference yield:

: 438468-97-4
iminodiacetic acid bis[2-(trimethylsilyl)ethyl] ester

: 438469-01-3
adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 75 percent / DCC / CH₂Cl₂ / 0 - 20 °C

2.1: Bu₃NH / ethanol

2.2: 53 mg / Na₂CO₃ / N,N-dimethyl-acetamide / 1 h / 80 °C

With dicyclohexyl-carbodiimide; In ethanol; dichloromethane;
DOI:10.1021/jo020040g

Reference yield:

: 438468-96-3
N-tert-butyloxycarbonyliminodiacetic acid bis[2-(trimethylsilyl)ethyl] ester

: 438469-01-3
adenosine 3',5'-cyclic([Rp]-{4-[N,N-bis(2-(trimethylsilyl)ethoxycarbonylmethyl)carbamoyl]-2-nitrophenyl}methyl) phosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / 4M HCl / dioxane / 1 h / 20 °C

2.1: 75 percent / DCC / CH₂Cl₂ / 0 - 20 °C

3.1: Bu₃NH / ethanol

3.2: 53 mg / Na₂CO₃ / N,N-dimethyl-acetamide / 1 h / 80 °C

With hydrogenchloride; dicyclohexyl-carbodiimide; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1021/jo020040g