2-METHYLBENZIMIDAZOLE-5-CARBONITRILE

Base Information

• Chemical Name: 2-METHYLBENZIMIDAZOLE-5-CARBONITRILE
• CAS No.: 92443-13-5
• Molecular Formula: C9H7N3
• Molecular Weight: 157.17
• Hs Code.: 2933990090
• Mol file: 92443-13-5.mol

Synonyms:1H-Benzimidazole-5-carbonitrile,2-methyl- (9CI);5(or 6)-Benzimidazolecarbonitrile, 2-methyl- (7CI);

Chemical Property of 2-METHYLBENZIMIDAZOLE-5-CARBONITRILE

Chemical Property:

• Boiling Point: 433.7 °C at 760 mmHg
• Flash Point: 141.2 °C
• PSA: 52.47000
• Density: 1.27 g/cm³
• LogP: 1.74298

Purity/Quality:

97% ^*data from raw suppliers

2-Methyl-1H-benzo[d]imidazole-5-carbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYLBENZIMIDAZOLE-5-CARBONITRILE

There total 14 articles about 2-METHYLBENZIMIDAZOLE-5-CARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic acid (64-19-7,77671-22-8) + 4-Amino 3-nitro-benzonitrile (6393-40-4) → 2-methyl-1H-benzoimidazole-5-carbonitrile (92443-13-5)

Guidance literature:

With tin(ll) chloride; at 130 ℃; for 0.0833333h; microwave;

DOI:10.1016/j.tetlet.2005.07.130

Reference yield: 90.0%

Triethyl orthoacetate (78-39-7) + 4-Amino 3-nitro-benzonitrile (6393-40-4) → 2-methyl-1H-benzoimidazole-5-carbonitrile (92443-13-5)

Guidance literature:

With 10% Pd/C; hydrogen; acetic acid; In methanol; at 20 ℃; under 760.051 Torr;

DOI:10.3987/COM-08-11384

Reference yield: 90.0%

malonic acid (141-82-2) + 4-cyano-1,2-phenylenediamine (17626-40-3) → 2-methyl-1H-benzoimidazole-5-carbonitrile (92443-13-5)

Guidance literature:

In 1,4-dioxane; at 120 ℃; for 8h; Green chemistry;

DOI:10.1039/c7ob03064a

upstream raw materials:

3,4-bis-acetylamino-benzonitrile

4-cyano-1,2-phenylenediamine

acetic acid

4-Amino 3-nitro-benzonitrile