tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate
CAS No.:1463484-94-7
Molecular Formula:C₂₄H₂₉N₃O₄S
Molecular Weight:455.578
Hs Code.:

Synonyms:tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

There total 12 articles about tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1463484-70-9
tert-butyl 3-amino-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

: 532-55-8
Benzoyl isothiocyanate

: 1463484-94-7
tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

Guidance literature:: In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1463484-94-7
tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: acetonitrile / 96 h / 0 - 20 °C

2: pyridine; hydroxylamine hydrochloride / ethanol / 4 h / 70 °C

3: toluene / 120 °C

4: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / chloroform / 18 h / Inert atmosphere

5: triethylamine / dichloromethane / 2 h

6: hydrogen / methanol / 20 °C / 760.05 Torr

7: tetrahydrofuran / 0 - 20 °C

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; hydroxylamine hydrochloride; hydrogen; triethylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; toluene; acetonitrile;

Reference yield:

: 1463484-40-3
5-allyl-6a-phenyl-3,3a,4,6-tetrahydro-1H-pyrrolo[3,4-c]isoxazole

: 1463484-94-7
tert-butyl 3-(benzoylcarbamothioylamino)-4-(hydroxymethyl)-3-phenyl-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1,3-dimethylbarbituric acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / chloroform / 18 h / Inert atmosphere

2: triethylamine / dichloromethane / 2 h

3: hydrogen / methanol / 20 °C / 760.05 Torr

4: tetrahydrofuran / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,3-dimethylbarbituric acid; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; chloroform;