(S)-diclofensine

Base Information

Chemical Name:(S)-diclofensine
CAS No.:50560-38-8
Molecular Formula:C₁₇H₁₇Cl₂NO
Molecular Weight:322.234
Hs Code.:

Synonyms:(S)-diclofensine

Suppliers and Price of (S)-diclofensine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (S)-diclofensine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (S)-diclofensine

There total 8 articles about (S)-diclofensine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₇H₁₅Cl₂NO₂

: 50560-38-8
(S)-diclofensine

Guidance literature:: With diisobutylaluminium hydride; In hexane; toluene; at 0 - 80 ℃;
DOI:10.1002/anie.201712829

Reference yield:

: 67165-56-4
Diclofensine

: 50560-45-7
(-)-4-(3,4-dichlorophenyl)-7-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

: 50560-38-8
(S)-diclofensine

Guidance literature:: With Chiralpak AD column; In n-heptane; diethylamine; isopropyl alcohol; Purification / work up; Resolution of racemate;

Reference yield:

: (S)-2-(3,4-dichlorophenyl)-2-hydroxy-N-methylacetamide

: 50560-38-8
(S)-diclofensine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 3 h / 0 - 20 °C

2: potassium carbonate; sodium bromide / toluene; Hexafluorobenzene / 48 h / 50 °C

3: diisobutylaluminium hydride / toluene; hexane / 0 - 20 °C

4: diisobutylaluminium hydride / tetrahydrofuran; water; acetone / 2 h / 0 - 20 °C

5: phosphorus pentoxide; trichlorophosphate / 6 h / 110 °C

6: diisobutylaluminium hydride / toluene; hexane / 0 - 80 °C

With phosphorus pentoxide; diisobutylaluminium hydride; potassium carbonate; triethylamine; sodium bromide; trichlorophosphate; In tetrahydrofuran; Hexafluorobenzene; hexane; dichloromethane; water; acetone; toluene;
DOI:10.1002/anie.201712829