(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

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Chemical Name:(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester
CAS No.:192067-30-4
Molecular Formula:C₃₉H₅₂N₈O₉
Molecular Weight:776.89
Hs Code.:

(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

Synonyms:(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

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Chemical Property of (S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

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Technology Process of (S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

There total 4 articles about (S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1738-72-3
L-serine benzyl ester

: 192067-29-1
(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoic acid propyl ester

: 192067-30-4
(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

Guidance literature:: at 25 ℃; clostripain, 0.025 M borate buffer, pH 8.0;
DOI:10.1002/anie.199710991

Reference yield:

: 192067-28-0
(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionic acid ethyl ester

: 192067-30-4
(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / -25 °C / chymotrypsin, 0.025 M borate buffer, pH 9.0

2: 83 percent / 25 °C / clostripain, 0.025 M borate buffer, pH 8.0

DOI:10.1002/anie.199710991

Reference yield:

: 949-67-7
L-tyrosine ethyl ester

: 192067-30-4
(S)-2-{(S)-2-[(S)-2-((S)-6-Amino-2-benzyloxycarbonylamino-hexanoylamino)-3-(4-hydroxy-phenyl)-propionylamino]-5-guanidino-pentanoylamino}-3-hydroxy-propionic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / 25 °C / clostripain, 0.025 M borate buffer, pH 8.0

2: 84 percent / -25 °C / chymotrypsin, 0.025 M borate buffer, pH 9.0

3: 83 percent / 25 °C / clostripain, 0.025 M borate buffer, pH 8.0

DOI:10.1002/anie.199710991