(1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol

Base Information

• Chemical Name: (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol
• CAS No.: 210291-44-4
• Molecular Formula: C₁₉H₄₀O₂Si
• Molecular Weight: 328.611

Synonyms:(1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol

Chemical Property of (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol

Chemical Property:

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Technology Process of (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol

There total 3 articles about (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(2R,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanone (210291-41-1) → (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol (210291-44-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; for 2h; Ambient temperature;

DOI:10.1016/S0957-4166(98)00013-5

Reference yield:

t-butyldimethylsiyl triflate (69739-34-0) → (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol (210291-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / DMAP, pyridine / Ambient temperature

2: 98 percent / NaBH₄ / methanol / 2 h / Ambient temperature

With pyridine; dmap; sodium tetrahydroborate; In methanol;

DOI:10.1016/S0957-4166(98)00013-5

Reference yield:

(1'R,2R,3R,6R)-2-(1'-hydroxypropyl)-6-isopropyl-3-methylcyclohexanone (201230-42-4) → (1S,2S,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanol (210291-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / DMAP, pyridine / Ambient temperature

2: 98 percent / NaBH₄ / methanol / 2 h / Ambient temperature

With pyridine; dmap; sodium tetrahydroborate; In methanol;

DOI:10.1016/S0957-4166(98)00013-5

upstream raw materials:

(2R,3R,6R)-2-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-propyl]-6-isopropyl-3-methyl-cyclohexanone

t-butyldimethylsiyl triflate

(1'R,2R,3R,6R)-2-(1'-hydroxypropyl)-6-isopropyl-3-methylcyclohexanone

Downstream raw materials:

(1'R,1S,2R,3R,6R)-2-(1'-hydroxypropyl)-6-isopropyl-3-methylcyclohexanol

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