4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

Base Information

Chemical Name:4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate
CAS No.:1351831-36-1
Molecular Formula:C₂₂H₂₈NO₈P
Molecular Weight:465.44
Hs Code.:

Synonyms:4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

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Chemical Property of 4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

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Technology Process of 4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

There total 8 articles about 4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1351831-50-9
4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-tris((tert-butyldimethylsilyl)oxy)hept-3-en-1-yl)amino)-2-oxoethyl)phenyl di-tert-butylphosphate

: 1351831-36-1
4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

Guidance literature:: With hydrogenchloride; methanol; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2011.10.014

Reference yield:

: C₂₂H₃₁NO₅

: 1351831-36-1
4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

Guidance literature:: Multi-step reaction with 6 steps

1.1: quinoline; hydrogen / ethyl acetate / 20 °C

2.1: phosphoric acid / tetrahydrofuran / 3 h / 0 - 20 °C

2.2: 0 °C / pH 8

3.1: 2,6-dimethylpyridine / dichloromethane / -78 - 20 °C / Inert atmosphere

4.1: t-butyldimethylsiyl triflate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

4.2: 0 °C / Inert atmosphere

5.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

5.2: 48 h / 0 - 20 °C / Inert atmosphere

6.1: hydrogenchloride; methanol / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; quinoline; hydrogenchloride; methanol; dmap; phosphoric acid; t-butyldimethylsiyl triflate; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/j.tet.2011.10.014

Reference yield:

: 1351831-46-3
C₃₇H₇₁NO₅Si₃

: 1351831-36-1
4-(2-(((2R,5R,6R,Z)-6-benzyl-2,5,7-trihydroxyhept-3-en-1-yl)amino)-2-oxoethyl)phenyl dihydrogenphosphate

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-butyldimethylsiyl triflate / dichloromethane / 2 h / -78 - 0 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

2.2: 48 h / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride; methanol / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With hydrogenchloride; methanol; dmap; t-butyldimethylsiyl triflate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2011.10.014